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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Clinical Development 781-970-6833
verve102clinicaltrials@lists.lilly.com


Study Location:

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Be Part of Research - Trial Details - A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

Recruiting

Open to: ALL

Age: 18.0 - 70.0

Medical Conditions

Heterozygous Familial Hypercholesterolemia
Premature Coronary Heart Disease


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease (CAD) Who Require Additional Lowering of LDL-C. VERVE-102 Uses Base-editing Technology Designed to Disrupt the Expression of the PCSK9 Gene in the Liver and Lower Circulating PCSK9 and LDL-C. This Study is Designed to Determine the Safety and Pharmacodynamic Profile of VERVE-102 in This Patient Population.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Apr 2024 Aug 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Intravenous (IV) infusion

Intervention Arm Group : Cohort 10: Single Fixed Dose;Cohort 1: Single Ascending Dose Escalation;Cohort 2: Single Ascending Dose Escalation;Cohort 3: Single Ascending Dose Escalation;Cohort 4: Single Ascending Dose Escalation;Cohort 5: Single Ascending Dose Escalation;Cohort 6: Single Ascending Dose Escalation;Cohort 7: Single Ascending Dose Escalation;Cohort 8: Single Ascending Dose Escalation;Cohort 9: Single Fixed Dose;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Clinical Study Center
    London
  • Clinical Study Center
    Manchester
  • Clinical Study Center
    Birmingham
  • Clinical Study Center
    Edinburgh
  • Clinical Study Center
    Nottingham


The study is sponsored by Verve Therapeutics, Inc.




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Read full details for Trial ID: NCT06164730
Last updated 31 March 2026

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