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Contact Information:

Study Contact 844-434-4210
Participate-In-This-Study1@its.jnj.com


Study Location:

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Be Part of Research - Trial Details - A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Neoplasms
Myeloproliferative Disorders
Thrombocytosis
Thrombocythemia, Essential


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to characterize safety and to determine the Recommended Phase 2 Dose (RP2D\[s\]) and optimal dosing schedule(s) of JNJ-88549968, in part 1 (Dose Escalation); to characterize the safety of JNJ- 88549968 at RP2D(s), in part 2 (Cohort Expansion).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2023 Oct 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : JNJ-88549968 will be administered.

Intervention Arm Group : Dose Escalation (Part 1) and Dose Expansion (Part 2);



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University College London Hospitals Nhs Foundation Trust
    London
    NW1 2PG
  • Churchill Hospital
    Oxford
    OX3 7LE


The study is sponsored by Janssen Research & Development, LLC




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Read full details for Trial ID: NCT06150157
Last updated 02 April 2025

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