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Contact Information:

Verastem Call Center 781-292-4204
RAMP301TrialSupport@verastem.com


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Be Part of Research - Trial Details - A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

Recruiting

Open to: FEMALE

Age: 18.0 - N/A

Medical Conditions

Ovarian Neoplasms
Carcinoma, Ovarian Epithelial


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with defactinib versus Investigator's choice of treatments (ICT) in subjects with recurrent LGSOC who have progressed on a prior platinum-based therapy.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Mar 2024 Oct 2028

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Avutometinib: administered orally

Intervention Arm Group : avutometinib + defactinib;

Intervention Type : DRUG
Intervention Description : Defactinib: administered orally

Intervention Arm Group : avutometinib + defactinib;

Intervention Type : DRUG
Intervention Description : administered intravenously

Intervention Arm Group : Investigator Choice of Treatment (ICT);

Intervention Type : DRUG
Intervention Description : administered intravenously

Intervention Arm Group : Investigator Choice of Treatment (ICT);

Intervention Type : DRUG
Intervention Description : administered orally

Intervention Arm Group : Investigator Choice of Treatment (ICT);

Intervention Type : DRUG
Intervention Description : administered orally

Intervention Arm Group : Investigator Choice of Treatment (ICT);



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Royal Marsden Hospital
    Sutton
    SM2 5PT
  • The Christie NHS Foundation Trust
    Manchester
  • Royal Marsden Hospital
    London
    SW7 3RP
  • University of Edinburgh Cancer Research Centre
    Edinburgh
  • Greater Glasgow and Clyde (GGC)
    Glasgow
    Scotland
    G120YN
  • Hope Cancer Trials Centre
    Leicester
    LE2 7LX
  • University College London Hospitals NHS Foundation Trust
    London
    NW1 2PG


The study is sponsored by Verastem, Inc. and is in collaboration with GOG Foundation; European Network of Gynaecological Oncological Trial Groups (ENGOT); Australia New Zealand Gynaecological Oncology Group; Korean Gynecologic Oncology Group.




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Read full details for Trial ID: NCT06072781
Last updated 05 June 2025

This page is to help you find out about a research study and if you may be able to take part

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