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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

BP44315 https://forpatients.roche.com/ 888-662-6728 (U.S. Only)
global-roche-genentech-trials@gene.com


Study Location:

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Be Part of Research - Trial Details - A First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7507062 in Participants With Systemic Lupus Erythematosus

A First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7507062 in Participants With Systemic Lupus Erythematosus

Recruiting

Open to: ALL

Age: 18.0 - 70.0

Medical Conditions

Lupus Erythematosus, Systemic


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of RO7507062 in participants with systemic lupus erythematosus (SLE). The study will have 2 parts: Part 1 is a single ascending dose-finding (SAD) part and Part 2 is a dose escalation with fractionated dosing part.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2023 Nov 2027

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : RO7507062 solution for injection will be administered SC as specified in each treatment part (arm).

Intervention Arm Group : Part 1: SAD: RO7507062;Part 2: Dose Escalation with Fractionated Dosing: RO7507062;

Intervention Type : DRUG
Intervention Description : When applicable, tocilizumab solution for infusion will be administered intravenously at 8 milligram per kilogram (mg/kg) for participants \>/= 30 kg or at 12 mg/kg for participants \< 30 kg.

Intervention Arm Group : Part 1: SAD: RO7507062;Part 2: Dose Escalation with Fractionated Dosing: RO7507062;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • UCL Hospital NHS Trust
    London
    NW1 2PG

BP44315 https://forpatients.roche.com/ 888-662-6728 (U.S. Only)
global-roche-genentech-trials@gene.com



The study is sponsored by Hoffmann-La Roche




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Read full details for Trial ID: NCT05835986
Last updated 11 June 2025

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