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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Miss Suzanne Carter
+44 (0)1617016941
suzanne.carter@manchester.ac.uk


Prof Emma Crosbie
+44 (0)1617016942
emma.crosbie@manchester.ac.uk


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Be Part of Research - Trial Details - Can a urine test improve uptake in cervical screening?
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Can a urine test improve uptake in cervical screening?

Recruiting

Open to: Female

Age: Adult

Manchester Manchester Manchester Manchester Altrincham Sale Manchester Manchester Cheadle Manchester Oldham Manchester Bury Oldham Ashton-under-lyne Knutsford Oldham Oldham Oldham Heywood Manchester Stockport Stockport Manchester Manchester Salford Manchester Manchester Manchester Manchester Manchester

Medical Conditions

Cervical screening

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Cervical screening can save lives, yet only 7 in 10 in the UK attend, the lowest rate in 20 years. Reasons include embarrassment, fear of examination and inconvenience. The aim of this study is to find out if self-collected urine and vaginal tests could increase uptake in cervical screening. The tests have the potential to remove many of the current barriers to screening. They can be taken at home at a time most convenient for the patient.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Aug 2024 01 Dec 2025

The researchers will work with GP practices across Greater Manchester to identify potential participants through overdue cervical screening lists. Participants will be randomly allocated into one of five groups.
1. Group 1 will be posted a urine sample collection pack.
2. Group 2 will be posted a vaginal sample collection pack.
3. Group 3 will receive a letter offering the choice of a urine or vaginal sample collection pack.
4. Group 4 will receive a letter offering a urine sample collection pack.
5. Group 5 will receive a letter offering a vaginal sample collection pack.
The researchers will also advertise through social media, at face-to-face community events, and using posters and leaflets in community settings. Participants recruited through this method will not be randomly allocated and will instead be offered the choice of a urine or vaginal self-sample kit.
Participants will self-collect a sample at home and complete a questionnaire. samples will be returned via Royal Mail. Samples will be tested for high-risk human papillomavirus – the virus known to cause cervical cancer. The researchers will look at how many samples are returned and whether there is a preference for urine or vaginal sample collection.


To be eligible to take part in this study participants must be aged 25-65 years and overdue cervical screening by 6 months or more

You can take part if:



You may not be able to take part if:


1. Pregnant2. Person without a uterus3. Unable to provide vaginal or a urine sample, including indwelling urinary catheter (for offering urine HPV testing only)4. Unable to understand the Participant Information Sheet and consent form5. Any condition that would compromise participant safety or data integrity6. Due screening in the next 3 months7. Type 1 objectors (i.e. those who dissent from their medical data being shared)


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Northern Moor Medical Practice
    216 Wythenshawe Road Northern Moor
    Manchester
    M23 0PH
  • The Maples Medical Centre
    2 Scout Drive Newall Green
    Manchester
    M23 2SY
  • Ancoats Urban Village Medical Practice
    Old Mill Street
    Manchester
    M4 6EE
  • Bodey Medical Centre
    28 Ladybarn Lane Fallowfield
    Manchester
    M14 6WP
  • St Johns Medical Centre
    Altrincham Health & Wellbeing Ctr 31-33 Market Street
    Altrincham
    WA14 1PF
  • Washway Road Medical Centre
    67 Washway Road
    Sale
    M33 7SS
  • Bowland Medical Centre
    52 Bowland Road `
    Manchester
    M23 1JX
  • Pds Medical - Hawthorn Medical Centre
    Fallowfield Retail Park Birchfields Road
    Manchester
    M14 6FS
  • Heald Green Health Centre 2
    Heald Green Health Centre Finney Lane Heald Green
    Cheadle
    SK8 3JD
  • West Gorton Medical Centre
    2 - 6 Clowes Street
    Manchester
    M12 5JE
  • John Street Medical Practice
    1 John Street
    Oldham
    OL8 1DF
  • Didsbury Medical Centre
    645 Wilmslow Road Didsbury
    Manchester
    M20 6BA
  • Tower Family Healthcare - Minden
    22 Derby Way
    Bury
    BL9 0NJ
  • Glodwick Primary Care Centre
    137 Glodwick Road Glodwick
    Oldham
    OL4 1YN
  • Ashton Medical Group
    Chapel Street
    Ashton-under-lyne
    OL6 6EW
  • Knutsford Medical Partnership
    Manchester Road Med/ctr 27-29 Manchester Road
    Knutsford
    WA16 0LY
  • Hollinwood Medical Practice
    1 Clive Street
    Oldham
    OL8 3TR
  • Hill Top Surgery
    Hilltop Surgery Fitton Hill Neighbourhood Centre Fircroft Road
    Oldham
    OL8 2QD
  • Village Medical Practice
    Shaw Crompton Medical Centre Westway Shaw
    Oldham
    OL2 8BF
  • Birtle View Medical Practice
    George Street
    Heywood
    OL10 4PW
  • Middleton Health Centre
    The Health Centre Unit F1 Middleton Shopping Centre Middleton
    Manchester
    M24 4EL
  • Brinnington Health Centre
    Brinnington Road Brinnington
    Stockport
    SK5 8BS
  • Park View Group Practice
    2 Longford Road West Reddish
    Stockport
    SK5 6ET
  • The Robert Darbishire Practice
    Rusholme Health Centre Walmer Street Rusholme
    Manchester
    M14 5NP
  • Springfield Medical Centre
    384 Liverpool Road Eccles
    Manchester
    M30 8QD
  • Langworthy Medical Practice
    250 Langworthy Road
    Salford
    M6 5WW
  • Surrey Lodge Group Practice
    11 Anson Road
    Manchester
    M14 5BY
  • Withington Medical Practice
    4-6 Copson Street Withington
    Manchester
    M20 3HE
  • The Mosslands Medical Practice
    Macdonald Road Irlam
    Manchester
    M44 5LH
  • Dickenson Road Medical Centre
    357-359 Dickenson Road Longsight
    Manchester
    M13 0WQ
  • Peterloo Medical Centre
    133 Manchester Old Road Middleton
    Manchester
    M24 4DZ

There are no expected risks or direct benefits expected for participants, however, a positive urine sample may prompt a non-attender to book routine cervical screening which in turn could prevent cervical cancer. Self-sampling may encourage more people to attend cervical screening in future.

Miss Suzanne Carter
+44 (0)1617016941
suzanne.carter@manchester.ac.uk


Prof Emma Crosbie
+44 (0)1617016942
emma.crosbie@manchester.ac.uk



The study is sponsored by University of Manchester and funded by NIHR Academy; Grant Codes: NIHR300650.



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Read full details for Trial ID: ISRCTN58902324

Or CPMS 62478

Last updated 17 June 2025

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