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Be Part of Research - Trial Details - A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (IMbrave152)

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (IMbrave152)

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Carcinoma
Carcinoma, Hepatocellular


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to assess the efficacy and safety of tiragolumab, an anti-TIGIT monoclonal antibody, when administered in combination with atezolizumab and bevacizumab as first-line treatment, in participants with unresectable, locally advanced or metastatic hepatocellular carcinoma (HCC).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2023 Sep 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Atezolizumab will be administered by intravenous (IV) infusion at a fixed dose of 1200 mg on Day 1 of each 21-day cycle.

Intervention Arm Group : Atezolizumab + Bevacizumab + Placebo;Atezolizumab + Bevacizumab + Tiragolumab;

Intervention Type : DRUG
Intervention Description : Bevacizumab will be administered by IV infusion at a dose of 15 mg/kg on Day 1 of each 21-day cycle.

Intervention Arm Group : Atezolizumab + Bevacizumab + Placebo;Atezolizumab + Bevacizumab + Tiragolumab;

Intervention Type : DRUG
Intervention Description : Tiragolumab will be administered by IV infusion at a fixed dose of 600 mg on Day 1 of each 21-day cycle.

Intervention Arm Group : Atezolizumab + Bevacizumab + Tiragolumab;

Intervention Type : OTHER
Intervention Description : Placebo matching tiragolumab will be administered by IV infusion on Day 1 of each 21-day cycle.

Intervention Arm Group : Atezolizumab + Bevacizumab + Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Hammersmith Hospital
    London
    W12 0HS
  • Royal Free Hospital
    London
    NW3 2QG
  • Western General Hospital
    Edinburgh
    EH4 2XU


The study is sponsored by Hoffmann-La Roche and is in collaboration with Chugai Pharmaceutical.




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Read full details for Trial ID: NCT05904886
Last updated 27 February 2025

This page is to help you find out about a research study and if you may be able to take part

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