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Contact Information:

Gilead Clinical Study Information Center 1-833-445-3230 (GILEAD-0)
GileadClinicalTrials@gilead.com


Study Location:

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Be Part of Research - Trial Details - Study With Various Immunotherapy Treatments in Participants With Lung Cancer

Study With Various Immunotherapy Treatments in Participants With Lung Cancer

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Lung Neoplasms
Carcinoma, Non-Small-Cell Lung


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to assess the objective response rate (ORR) of immunotherapy-based combination therapy and to assess the safety and tolerability of immunotherapy-based combination therapy.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2023 Dec 2027

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Administered as specified in the treatment arm

Intervention Arm Group : A1: Domvanalimab + Zimberelimab;A2: Domvanalimab + Zimberelimab;B2: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy;B3: Domvanalimab + Quemliclustat + Zimberelimab + Platinum Doublet Chemotherapy;B4: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy;B5: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy;C2: Domvanalimab + Zimberelimab + Docetaxel;

Intervention Type : DRUG
Intervention Description : Administered as specified in the treatment arm

Intervention Arm Group : A3: Quemliclustat + Zimberelimab;B1: Quemliclustat + Zimberelimab + Platinum Doublet Chemotherapy;B3: Domvanalimab + Quemliclustat + Zimberelimab + Platinum Doublet Chemotherapy;C1: Quemliclustat + Zimberelimab + Docetaxel;

Intervention Type : DRUG
Intervention Description : Administered as specified in the treatment arm

Intervention Arm Group : A1: Domvanalimab + Zimberelimab;A2: Domvanalimab + Zimberelimab;A3: Quemliclustat + Zimberelimab;B1: Quemliclustat + Zimberelimab + Platinum Doublet Chemotherapy;B2: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy;B3: Domvanalimab + Quemliclustat + Zimberelimab + Platinum Doublet Chemotherapy;B4: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy;B5: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy;C1: Quemliclustat + Zimberelimab + Docetaxel;C2: Domvanalimab + Zimberelimab + Docetaxel;

Intervention Type : DRUG
Intervention Description : Administered as specified in the treatment arm

Intervention Arm Group : C1: Quemliclustat + Zimberelimab + Docetaxel;C2: Domvanalimab + Zimberelimab + Docetaxel;

Intervention Type : DRUG
Intervention Description : Administered as specified in the treatment arm

Intervention Arm Group : B1: Quemliclustat + Zimberelimab + Platinum Doublet Chemotherapy;B2: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy;B3: Domvanalimab + Quemliclustat + Zimberelimab + Platinum Doublet Chemotherapy;B4: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy;B5: Domvanalimab + Zimberelimab + Platinum Doublet Chemotherapy;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Barts Health NHS Trust St Bartholomew's Hospital
    London
    W1G 6AF

Gilead Clinical Study Information Center 1-833-445-3230 (GILEAD-0)
GileadClinicalTrials@gilead.com



The study is sponsored by Gilead Sciences and is in collaboration with Arcus Biosciences, Inc..




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Read full details for Trial ID: NCT05676931
Last updated 26 June 2025

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