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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Stuart Jones 0207 848 4506
stuart.jones@kcl.ac.uk


Study Location:

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Be Part of Research - Trial Details - TRANS-FOODS: Preventing Peanut Allergy Through Improved Understanding of the Transcutaneous Sensitisation Route, Novel Food Processing and Skin Care Adaptations

TRANS-FOODS: Preventing Peanut Allergy Through Improved Understanding of the Transcutaneous Sensitisation Route, Novel Food Processing and Skin Care Adaptations

Recruiting

Open to: ALL

Age: 18.0 - 65.0

Medical Conditions

Hypersensitivity
Food Hypersensitivity
Peanut Hypersensitivity


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This project aims to study the immune responses to peanut allergen in those with a skin barrier defect with and without skin massage, specifically it aims to:

1. Establish if peanut allergen components can pass into human skin through regular massage using the peanut protein-containing extract. 2. Clarify whether this effect is amplified in those with an impaired skin barrier (AD and dry skin vs healthy controls). 3. Assess whether peanut protein components can be detected in interstitial skin fluid (ISF) using a suction device. 4. Test whether peanut protein components present in ISF are able to induce activation of basophils in blood of peanut allergic donors. 5. Assess whether the transcutaneous uptake of peanut protein can be reduced by the prior use of a barrier enhancing cream.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Apr 2024 May 2025

INTERVENTIONAL

Intervention Type : OTHER
Intervention Description : Application of the barrier enhancing preparation around 30 minutes before application of the peanut protein extract +/- massage after extract applicationÍľ

Intervention Arm Group : Intervention of the barrier enhancing preparation;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Unit for Population-Based Dermatology Research
    London
    SE1 7EH


The study is sponsored by King's College London and is in collaboration with University Hospital, Bonn; Institut Curie; Charite University, Berlin, Germany; Levantine UK.




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Read full details for Trial ID: NCT05407012
Last updated 03 May 2024

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