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Be Part of Research - Trial Details - A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension

A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension

Not Recruiting

Open to: ALL

Age: 18.0 - 130.0

Medical Conditions

Hypertension


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a Phase III, multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the safety, tolerability and the effect of 2 mg Baxdrostat vs. placebo, administered QD orally, on the reduction of SBP, measured by average 24-hour ABPM in 212 participants with rHTN (defined as seated SBP ≥ 140 mmHg at Screening and mean ambulatory SBP ≥ 130 mmHg at baseline, despite a stable regimen of ≥ 3 antihypertensive agents, one of which is a diuretic).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Mar 2024 Sep 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Baxdrostat tablet administered orally, once daily (QD). Unit dose strength:

• 2 mg per tablet.

Intervention Arm Group : 2 mg baxdrostat;

Intervention Type : DRUG
Intervention Description : Placebo tablet matching baxdrostat, administered orally, once daily (QD).

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    London
    E1 1BB
  • Research Site
    Corby
    NN17 2UR
  • Research Site
    Prescot
    L35 5DR
  • Research Site
    Yate
    BS37 4AX
  • Research Site
    Swindon
    SN3 6BB
  • Research Site
    London
    W6 7HY
  • Research Site
    Thetford
    IP24 1JD
  • Research Site
    Weston-Super-Mare
    BS24 7PR


The study is sponsored by AstraZeneca




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Read full details for Trial ID: NCT06168409
Last updated 20 May 2025

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