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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Clinical Trials Coordinator
+442075943767
mast-trial@imperial.ac.uk
Julian Marchesi
02033126197
j.marchesi@imperial.ac.uk
Acute Lymphoblastic Leukaemia Acute Leukemia of Ambiguous Lineage Chronic Myeloid Leukemia Chronic Myelomonocytic Leukemia Myelodysplastic Syndrome Acute Myeloid Leukemia
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
The goal of this clinical trial is to test the ability to restore gut microbiota to healthier levels in patients with blood cancers scheduled to have stem cell transplant.
The main questions it aims to answer are:
* Tolerability and acceptability of intestinal microbiota transplantation (IMT) versus placebo (as assessed via patient perspective questionnaires
* Changes in gut microbiome diversity across all timepoints
* Markers of general health, infective/microbiological and haematological outcomes including, days of fever, admission to intensive care unit, survival, non-relapsed mortality, and incidence of graft-versus-host disease across all time points measured.
Participants will be asked at their routine follow up visits to,
* Provide stool, urine and blood samples at the scheduled study visits
* Complete questionnaires at selected visits
* Swallow either Placebo or IMT capsules once at the second study visit which will occur 2 weeks prior to the stem cell transplant (+/-3 days)
Researchers will compare IMT capsules and Placebo to investigate the change in gut microbiota diversity.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
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You can take part if:
You may not be able to take part if:
This is in the inclusion criteria above
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Julian Marchesi
02033126197
j.marchesi@imperial.ac.uk
Clinical Trials Coordinator
+442075943767
mast-trial@imperial.ac.uk
The study is sponsored by Imperial College London
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
