Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Amgen Call Center 866-572-6436
medinfo@amgen.com


Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia

Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia

Recruiting

Open to: ALL

Age: 40.0 - 100.0

Medical Conditions

Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Lymphoid


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The safety run-in part of the study aims to evaluate the safety and tolerability of blinatumomab alternating with low-intensity chemotherapy. The phase 3 part of the study aims to compare event-free survival (EFS) and overall survival (OS) of participants receiving blinatumomab alternating with low-intensity chemotherapy to EFS and (OS) of participants receiving standard of care (SOC) chemotherapy.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2021 Jan 2027

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Continuous intravenous (cIV) infusion

Intervention Arm Group : Phase 3: Blinatumomab alternating with low-intensity chemotherapy;Safety Run-in: Blinatumomab alternating with low-intensity chemotherapy;

Intervention Type : DRUG
Intervention Description : Intravenous (IV), oral (PO), subcutaneous (SC), or intrathecal (IT) administration.

Intervention Arm Group : Phase 3: Blinatumomab alternating with low-intensity chemotherapy;Safety Run-in: Blinatumomab alternating with low-intensity chemotherapy;

Intervention Type : DRUG
Intervention Description : Intravenous (IV), oral (PO), subcutaneous (SC), or intrathecal (IT) administration.

Intervention Arm Group : Phase 3: Standard of care (SOC) chemotherapy;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Kings College Hospital
    London
    SE5 9RS
  • University College London
    London
    NW1 2PG

Amgen Call Center 866-572-6436
medinfo@amgen.com



The study is sponsored by Amgen




We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: NCT04994717
Last updated 09 April 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.