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Be Part of Research - Trial Details - Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension

Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension

Medical Conditions

Hypertension


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a Phase 3 trial to evaluate the BP-lowering effect of lorundrostat (an aldosterone synthase inhibitor) in subjects with uncontrolled and resistant hypertension taking between 2 and 5 anti-hypertensive (AHT) medications.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2023 Dec 2024

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Placebo once daily (QD) for 12 weeks

Intervention Arm Group : Placebo;

Intervention Type : DRUG
Intervention Description : 50 mg lorundrostat Dose 1 once daily (QD) for 12 weeks

Intervention Arm Group : Dose 1;

Intervention Type : DRUG
Intervention Description : 50 mg lorundrostat Dose 1 once daily (QD) for 6 weeks then 100 mg lorundrostat Dose 2 once daily (QD) for 6 weeks for subjects who meet prespecified criteria

Intervention Arm Group : Dose 2;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Aberdeen Royal Infirmary
    Aberdeen
    AB25 2ZN
  • Epsom and St Helier University Hospitals NHS Trust
    Carshalton
    SM5 1AA
  • East Kent Hospitals University NHS Foundation Trust
    Canterbury
    CT1 3NG
  • Sheffield Teaching Hospitals NHS Foundation Trust - Northern General Hospital
    Sheffield
    S5 7AU
  • Queen Mary University of London (QMUL) - Barts and The London School of Medicine and Dentistry - William Harvey Research Institute (WHRI) - William Harvey Heart Centre (WHHC)
    London
    Great Britain
    EC1M 6BQ
  • Fowey River Practice - Fowey Surgery
    Fowey
    Great Britain
    PL23 1DT
  • Knowle House Surgery
    Plymouth
    Great Britain
    PL5 3JB
  • The Rame Group Practice (Dr. DAVIS & Partners) - Penntorr Health
    Torpoint
    Great Britain
    PL11 2TB
  • NHS Greater Glasgow and Clyde (NHSGGC)
    Glasgow
    G12 8TA
  • Newquay Health Centre
    Newquay
    TR7 1RU
  • University Hospitals Birmingham NHS Foundation Trust - Birmingham Regional Severe Asthma Service (BRSAS)
    Birmingham
    B9 5SS
  • Cambridge University Hospitals NHS Foundation Trust - Addenbrooke's Hospital (AH)
    Canterbury
    Kent
    CT1 3NG
  • FutureMeds - Stockton-on-Tees
    Stockton-on-Tees
    TS19 8PE
  • Rowden Surgery Rowden Medical Partnership
    Chippenham
    SN15 2SB


The study is sponsored by Mineralys Therapeutics Inc.




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Read full details for Trial ID: NCT06153693
Last updated 21 February 2025

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