Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Amgen Call Center 866-572-6436
medinfo@amgen.com


Study Location:

Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Recruiting

Open to: ALL

Age: 18.0 - 100.0

Medical Conditions

Lung Neoplasms
Carcinoma, Non-Small-Cell Lung


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The primary objective of this study is to compare progression-free survival (PFS) in participants who receive sotorasib with platinum doublet chemotherapy versus participants who receive pembrolizumab with platinum doublet chemotherapy.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Nov 2023 Jun 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Oral administration

Intervention Arm Group : Sotorasib combined with carboplatin and pemetrexed;

Intervention Type : DRUG
Intervention Description : Intravenous administration

Intervention Arm Group : Pembrolizumab combined with carboplatin and pemetrexed;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Nottingham City Hospital
    Nottingham
    NG5 1PB
  • Raigmore Hospital
    Inverness
    IV2 3UJ
  • Royal Cornwall Hospital
    Truro
    TR1 3LQ
  • Royal Marsden Hospital
    London
    SW3 6JJ
  • Queen Elizabeth Hospital Birmingham
    Birmingham
    B15 2TH
  • Royal Marsden Hospital
    Sutton
    SM2 5PT
  • Torbay Hospital
    Torquay
    TQ2 7AA
  • Mount Vernon Cancer Centre
    Northwood
    HA6 2RN

Amgen Call Center 866-572-6436
medinfo@amgen.com



The study is sponsored by Amgen




We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?

Read full details for Trial ID: NCT05920356
Last updated 09 April 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.