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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Gisela
Orozco
gisela.orozco@manchester.ac.uk
Gisela
Orozco
gisela.orozco@manchester.ac.uk
Arthrosis
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Background
Many of the genes involved in osteoarthritis (OA) have now been identified but the DNA changes and its role in OA development is not well understood. DNA is deoxyribonucleic acid, and it directs our body to make proteins. RNA, ribonucleic acids are intermediate messengers, also essential for protein production. RNA sequencing provides information about the presence and quantity of these messengers. Integrating genetic information with datasets including gene expression levels and protein levels, increase our understanding of the pathogenesis of OA.
Why is it important?
Osteoarthritis is the most common joint disease worldwide, affecting approximately 10% of men and 18% of women over 60. It is a whole joint disease impacting all joint tissues causing pain and disability. Certain forms of OA are known to have a strong genetic component.
The questions it will answer……
This data will provide insights into the mechanisms involved in the development of OA.
Potential Benefits
Improve the understanding of the genetic mechanisms in OA using gene expression data, proteomic data, and epigenetic data.
Study Design
Study participants are recruited from patients undergoing knee arthroscopy or total knee replacement. Discard tissue from these procedures will be transported to the University of Manchester for genomic analyses. A blood sample will also be obtained for genetic and proteomic analysis. Study participants who are not affected by osteoarthritis but undergoing routine diagnostic or therapeutic knee arthroscopy will also be recruited to this study to act as a control group. Further sequencing of synthetic libraries will be performed at the Genomics Core Facility at the Helmholtz Zentrum München, Germany, or another service provider such as Novogene. Demographic information, imaging results and standard of care patient reported outcome measures on pain and function will be used to support the interpretation of the genomic analyses.
Funding the Research
This study will initially be funded by a grant held by Principal Investigator, Dr Gisela Orozco at The University of Manchester. This includes Wellcome Trust (Senior Fellowship in Basic Biomedical Science), Arthritis Research UK Centre of Excellence in Genetics and Genomics and Manchester NIHR Biomedical Research Centre: Musculoskeletal Theme
Where it will be Recruiting
Study participants will be recruited at the Manchester University Foundation Trust, elective orthopaedic clinics by orthopaedic consultants named on the delegation log for this study.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cross-sectional;
You can take part if:
You may not be able to take part if:
Discarded tissue from children or adults lacking the capacity to consent to undergo open or arthroscopic joint surgery with a musculoskeletal disorder of interest.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by University of Manchester and funded by VERSUS ARTHRITIS .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 56140
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