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Be Part of Research - Trial Details - Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors

Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors

Not Recruiting

Open to: ALL

Age: 18.0 - 90.0

Medical Conditions

Esophageal Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The goal of this observational study is to learn about long term symptoms in oesophageal cancer survivors. The main question it aims to answer is are:

* Study the changes in gut bacteria by examining saliva, stool and blood. * Investigate the products of bacteria in breath to develop a non-invasive breath test to detect the changes in gut bacteria. * Develop new strategies to treat this change and trial new treatments to improve quality- of-life in oesophageal cancer survivors.

Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath, saliva, blood, urine, stool and complete validated healthy-related quality-of-life questionnaires.

Researchers will compare symptomatic and asymptomatic participants to detect the changes stated above.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Mar 2022 Oct 2025

OBSERVATIONAL

Intervention Type : DIAGNOSTIC_TEST
Intervention Description : Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath.

Intervention Arm Group : Oesophageal adenocarcinoma survivors;

Intervention Type : DIAGNOSTIC_TEST
Intervention Description : Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of saliva.

Intervention Arm Group : Oesophageal adenocarcinoma survivors;

Intervention Type : DIAGNOSTIC_TEST
Intervention Description : Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of blood.

Intervention Arm Group : Oesophageal adenocarcinoma survivors;

Intervention Type : DIAGNOSTIC_TEST
Intervention Description : Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of urine.

Intervention Arm Group : Oesophageal adenocarcinoma survivors;

Intervention Type : DIAGNOSTIC_TEST
Intervention Description : Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of stool.

Intervention Arm Group : Oesophageal adenocarcinoma survivors;

Intervention Type : DIAGNOSTIC_TEST
Intervention Description : Participants will attend an outpatient clinic and complete validated healthy-related quality-of-life questionnaires.

Intervention Arm Group : Oesophageal adenocarcinoma survivors;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Imperial College Healthcare NHS Trust
    London
  • Barking, Havering and Redbridge University Hospitals NHS Trust
    London
  • West Hertfordshire NHS Teaching Hospitals
    London


The study is sponsored by Imperial College London and is in collaboration with Imperial College Healthcare NHS Trust; West Hertfordshire Teaching Hospitals NHS Trust; Barking, Havering and Redbridge University Hospitals NHS Trust.




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Read full details for Trial ID: NCT06302660
Last updated 24 January 2025

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