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Be Part of Research - Trial Details - A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia

A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Waldenstrom Macroglobulinemia
Waldenstrom's Macroglobulinemia Recurrent
Waldenstrom's Macroglobulinemia Refractory


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study will evaluate the safety and efficacy of the BCL2 inhibitor sonrotoclax (BGB-11417) in participants with relapsed/refractory Waldenström's Macroglobulinemia (R/R WM) and in combination with zanubrutinib in adult participants with previously untreated WM.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Oct 2023 Sep 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Administered orally as a tablet.

Intervention Arm Group : Cohort 1;Cohort 2;Cohort 3;Cohort 4;

Intervention Type : DRUG
Intervention Description : Administered orally as a capsule.

Intervention Arm Group : Cohort 4;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University College Hospital
    London
    NW1 2PG
  • Churchill Hospital Oxford University Hospital Nhs Trust
    Headington
    OX3 7LE
  • Royal Marsden Nhs Foundation Royal Marsden Hospital
    Sutton
    SM2 5PT
  • Nhs Highland
    Inverness
    IV2 3BW
  • St Jamess University Hospital
    Leeds
    LS9 7TF
  • University Hospitals Dorset
    Bournemouth
    BH7 7DW
  • The Christie Nhs Foundation Trust Manchester
    Manchester
    M20 4BX
  • Beatson West of Scotland Cancer Centre
    Glasgow
    G12 0YN
  • Plymouth Hospitals Nhs Trust
    Plymouth
    PL6 8DH


The study is sponsored by BeOne Medicines




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Read full details for Trial ID: NCT05952037
Last updated 30 December 2025

This page is to help you find out about a research study and if you may be able to take part

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