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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Ms Samantha Roberts
+44 (0)1480 453 437
samantha.roberts@cyted.ai


Dr Sarah Killcoyne
+44 (0)1480 453 437
sarah.killcoyne@cyted.ai


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Be Part of Research - Trial Details - Developing new tests to monitor patients with eosinophilic oesophagitis using capsule sponge instead of endoscopy
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Developing new tests to monitor patients with eosinophilic oesophagitis using capsule sponge instead of endoscopy

Recruiting

Open to: All Genders

Age: Adult

Nottingham Stevenage Darlington

Medical Conditions

Eosinophilic oesophagitis (EoE)

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Eosinophilic oesophagitis (EoE) is a disease of the oesophagus (“food pipe”) affecting tens of thousands of adults and children across the UK. Related to asthma, allergies and other chronic inflammatory conditions, this disease has been on the rise in recent years. However, it can often take years and even several trips to A&E due to food getting stuck in the oesophagus before a diagnosis is made. Treatments are available, but not all patients respond to treatment and the only way to check response is an invasive endoscopy. Finding the right treatment can take multiple endoscopies in a single year, and even after one is found a patient may need endoscopies throughout their life. This study aims to improve patient care in EoE in two ways: by decreasing the need for endoscopy through the use of minimally-invasive capsule sponge testing to collect cells from the oesophagus, and by providing a personalised predictive test for therapy response.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Feb 2024 31 Oct 2025

Participants are offered both an endoscopy and a capsule sponge test. The resulting information will be clinically validated diagnoses alongside biomarker measurements, providing a clear readout for personalised EoE management.


Patients over 18 years old with EoE

You can take part if:



You may not be able to take part if:


1. Age <18 years2. Strictures or severe rings at most recent endoscopy that prevent passage of adult 9.8 mm gastroscope3. Oesophageal dilatation within 24 months of clinic visit4. Previous oesophageal perforation or surgical resection5. Oesophagogastric malignancy 6. Oesophageal varices7. Bolus obstruction since last endoscopy requiring hospital visit8. Previous fundoplication or complicated hiatus hernia9. Patient on warfarin with INR>=3


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Nottingham University Hospitals NHS Trust - Queen's Medical Centre Campus
    Nottingham University Hospital Derby Road
    Nottingham
    NG7 2UH
  • East and North Hertfordshire NHS Trust
    Lister Hospital Coreys Mill Lane
    Stevenage
    SG1 4AB
  • County Durham and Darlington NHS Foundation Trust
    Darlington Memorial Hospital Hollyhurst Road
    Darlington
    DL3 6HX

This study is to assess if a simpler test, known as capsule sponge, can be used to regularly manage EoE instead of endoscopy. The capsule sponge test is:
1. Quick, the procedure only lasts for 10 minutes
2. Less invasive and does not require any sedation
3. A more comfortable experience (as stated by other patients)
4. Well-tested, more than 17,000 tests have been given to patients with no serious side effects
Disadvantages of taking part:
1. Participants may experience a mild sore throat for up to 24 hours and in some people, this may last for a few days. Paracetamol and throat lozenges can be taken to help.
2. There is a very small risk (less than 1 in 2,000) of the sponge becoming detached from the thread, or the nurse is unable to remove it. If this happens, it will be easily removed during your endoscopy.
3. There is a very small risk that you may have some bleeding. If this happens, you will be assessed by your consultant and clinical nurse. This is unlikely to need any intervention but if required an endoscopy could be performed to find and stop the bleeding. This has never been needed in 10+ years of tests.

Ms Samantha Roberts
+44 (0)1480 453 437
samantha.roberts@cyted.ai


Dr Sarah Killcoyne
+44 (0)1480 453 437
sarah.killcoyne@cyted.ai



The study is sponsored by Cyted Ltd and funded by Innovate UK.



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What will you do next?
Read full details for Trial ID: ISRCTN14071734

Or CPMS 59420

Last updated 28 February 2025

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

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