We'd like your feedback
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
James Scott
+44 207 848 0002
james.1.scott@kcl.ac.uk
Guy Gitlin-Leigh
guy.1.gitlin-leigh@kcl.ac.uk
Schizophrenia Schizophrenia, Treatment-Resistant
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
The goal of this basic science study is to to explore the responsivity of glutamate in the brain of treatment-resistant schizophrenia patients to the drug riluzole. The main aims of the study are:
To assess the role of glutamate in treatment-resistant schizophrenia using magnetic resonance spectroscopy.
To assess the relationship between glutamate levels and brain structural and functional measures (using: structural MRI; functional MRI (fMRI) and arterial spin labelling (ASL)) at baseline.
To assess the relationship between longitudinal change in glutamate levels and brain structural and functional measures.
To assess the relationship between longitudinal change in glutamate levels and changes in psychopathology.
The researchers will compare the changes with healthy controls and those without treatment-resistant schizophrenia.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
You may not be able to take part if:
This is in the inclusion criteria above
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by King's College London and is in collaboration with South London and Maudsley NHS Foundation Trust.
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
