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Contact Information:

Thamanna Begum
Thamanna.begum@qmul.ac.uk


Dr Charles Marshall
Charles.marshall@qmul.ac.uk


Dr Charles Marshall
Charles.marshall@qmul.ac.uk


Harshinder Virdee
harshinder.virdee@nihr.ac.uk


Dr Charles Marshall
Charles.marshall@qmul.ac.uk


Study Location:

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Be Part of Research - Trial Details - DIADEM

DIADEM

Medical Conditions

Organic, including symptomatic, mental disorders


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


We have developed simple hearing tests that measure subtle changes in the brain. Our team has expertise in auditory neuroscience, early detection of dementia , and the diagnostic pathway in NHS memory clinics. It typically takes over three years to get a dementia diagnosis from the time symptoms start. Timely and accurate diagnosis will be vital to ensure access to future treatments that may be able to slow down dementia. However, current diagnostic tests are ‘blunt’ and expensive. Those who are more deprived or from minoritised ethnic groups tend to be diagnosed later and less accurately.
We will evaluate digital hearing tests in a “real-world” setting in memory clinics that serve a diverse and deprived population. We will recruit 500 people attending memory clinics to be evaluated for dementia and 100 healthy controls. We will assess how well our hearing tests identify patients with dementia at initial assessment, and then follow patients for 2 years to establish how well they predict dementia in those who did not receive a diagnosis of dementia initially, allowing some patients with dementia to have earlier access to treatment and support, and some patients without dementia to have earlier reassurance. We will also assess whether our hearing tests have added value when used alongside emerging blood tests for dementia.
The technology is designed to be a cost-effective decision support tool that could be used throughout the NHS as it will require only a computer and internet connection. We will assess the potential cost-effectiveness during the project based on data we acquire about how much it might improve dementia diagnosis.
We will co-produce the research with members of the public and clinicians involved in patient care, working with them to understand the value of the technology to patients, and how best to communicate the outputs in clinical settings.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

11 Apr 2024 31 Jul 2025

Observational

Observational type: Validation of investigation /therapeutic procedures;



You can take part if:



You may not be able to take part if:


There will be no exclusion criteria for those attending memory clinics Healthy controls will be excluded if they have significant neurological or psychiatric comorbidities for example a major chronic illness such as multiple sclerosis, Parkinson's disease, schizophrenia or bipolar affective disorder.


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Bradford Royal Infirmary
    Duckworth Lane
    Bradford
    West Yorkshire
    BD9 6RJ
  • King's College Hospital (denmark Hill)
    Denmark Hill
    London
    Greater London
    SE5 9RS
  • Derriford Hospital
    Derriford Road
    crownhill
    Plymouth
    Devon
    PL6 8DH
  • Salford Royal
    Stott Lane
    Salford
    Greater Manchester
    M6 8HD
  • Musgrove Park Hospital
    Musgrove Park
    Taunton
    TA1 5DA
  • University College Hospital
    235 Euston Road
    London
    Greater London
    NW1 2BU
  • Blandford Community Hospital
    Milldown Road
    Blandford Forum
    Dorset
    DT11 7DD
  • Charlton Lane Site
    Charlton Lane
    Cheltenham
    Gloucestershire
    GL53 9DZ
  • Trust Headquarters
    9 Alie Street
    aldgate
    London
    Greater London
    E1 8DE
  • Goodmayes Hospital - Trust Headquarters
    Tantallon House
    barley Lane
    Ilford
    Essex
    IG3 8XJ
  • The Royal London Hospital
    Whitechapel
    London
    Greater London
    E1 1BB
  • Wonford House
    Wonford House Hospital
    dryden Road
    Exeter
    Devon
    EX2 5AF
  • Cambridgeshire And Peterborough Mental Health Partnership Tr Hq
    Elizabeth House, Fulbourn Hospital
    cambridge Road
    fulbourn
    Cambridge
    Cambridgeshire
    CB21 5EF
  • St Mary's Health Campus
    Milton Road
    Portsmouth
    Hampshire
    PO3 6AD
  • Boscombe Community Hospital
    11 Shelley Road
    Bournemouth
    Dorset
    BH1 4JQ
  • Barnes Hospital
    South Worple Way
    London
    Greater London
    SW14 8SU
  • Memorial Hospital
    Shooters Hill
    woolwich
    London
    Greater London
    SE18 3RG
  • St Mary's Community Healthcare
    West Wing
    milton Road
    Portsmouth
    PO3 6AD

Dr Charles Marshall
Charles.marshall@qmul.ac.uk


Harshinder Virdee
harshinder.virdee@nihr.ac.uk


Dr Charles Marshall
Charles.marshall@qmul.ac.uk


Thamanna Begum
Thamanna.begum@qmul.ac.uk


Dr Charles Marshall
Charles.marshall@qmul.ac.uk



The study is sponsored by Queen Mary University of London and funded by NIHR Central Commissioning Facility (CCF) .




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for Trial ID: CPMS 60651

Last updated 03 March 2025

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