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Be Part of Research - Trial Details - A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Lymphoma
Leukemia
Leukemia, Lymphoid
Leukemia, Lymphocytic, Chronic, B-Cell


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The goal of this study is to evaluate nemtabrutinib compared with investigator's choice of ibrutinib or acalabrutinib in participants with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who have not received any prior therapy. The primary hypotheses are that (1) nemtabrutinib is non-inferior to ibrutinib or acalabrutinib with respect to objective response rate (ORR) per International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Criteria 2018 by blinded independent central review (BICR) and (2) nemtabrutinib is superior to ibrutinib or acalabrutinib with respect to progression free survival (PFS) per iwCLL Criteria 2018 by BICR.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2023 Sep 2032

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Administered orally

Intervention Arm Group : Nemtabrutinib;

Intervention Type : DRUG
Intervention Description : Administered orally

Intervention Arm Group : Ibrutinib/Acalabrutinib;

Intervention Type : DRUG
Intervention Description : Administered orally

Intervention Arm Group : Ibrutinib/Acalabrutinib;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • The Churchill Hospital ( Site 3007)
    Oxford
    Oxfordshire
    OX3 7LE
  • GenesisCare - Cambridge ( Site 3001)
    Newmarket
    Suffolk
    CB8 7XN
  • GenesisCare - Windsor ( Site 3002)
    Windsor
    Windsor And Maidenhead
    SL4 3HD
  • St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 3006)
    London
    London, City Of
    EC1A 7BE
  • Southmead Hospital ( Site 3010)
    Bristol
    Bristol, City Of
    BS10 5NB
  • Barnet Hospital ( Site 3005)
    Barnet
    EN5 3DJ
  • St James's University Hospital ( Site 3004)
    Leeds
    LS9 7TF
  • City Hospital, Nottingham University Hospitals NHS Trust ( Site 3003)
    Nottingham
    NG5 1PB


The study is sponsored by Merck Sharp & Dohme LLC




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Read full details for Trial ID: NCT06136559
Last updated 19 June 2025

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