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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Prof
Robin
Choudhury
robin.choudhury@cardiov.ox.ac.uk
Study
Team
clinicalresearch@cardiov.ox.ac.uk
Jason
Chai
jason.chai@cardiov.ox.ac.uk
Prof
Robin
Choudhury
robin.choudhury@cardiov.ox.ac.uk
Ischaemic heart diseasesDiabetes mellitus
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Patients with diabetes have a higher risk of heart attack and worse outcomes. While high glucose levels seem to drive this risk, glucose-lowering medicines do not reduce the risk. Work by Professor Choudhury’s group has shown that high glucose levels lead to re-programming of a type of white blood cell involved in processes such as inflammation, that lead to narrowing of the blood vessels in the heart and consequently heart attack. Specifically, high glucose makes cells in the bone marrow change the way they read their DNA, making them more likely to cause harm and less able to repair damage.
In parallel, there is a growing body of work linking age-related DNA mutations that occur in bone marrow stem cells with increased risk of heart disease. There is also evidence that bone marrow stem cell clones have offspring which only contribute to the platelet lineage (platelet-biased); platelets are essential to the clotting of blood. Professor Mead’s group has pilot data detecting these platelet-biased clones in the blood of elderly hospital inpatients, and hypothesise that they are associated with heart disease due to the role of platelets.
We aim to determine how common these related phenomena are in patients who present with heart disease, with and without diabetes, using tests that we and others have developed which we will refine to make them easier to use and more affordable. These tests include analysis of genetic material from blood and for some patients who undergo cardiac surgery, bone marrow from the breastbone. We will also look at how patterns of blood glucose levels affect these processes. Lastly, we seek to characterise the pattern of blood vessel narrowing in the heart that seem to affect patients with diabetes and to understand whether it relates to the phenomena we are aiming to describe.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Cohort study;
You can take part if:
You may not be able to take part if:
1. Participant is unwilling or unable to give informed consent 2. Aged under 18 years 3. Any impediment to communication which, in the opinion of the investigator, might prevent the investigator communicating effectively with the patient during the study which could cause a safety or reliability concern. 4. Any other condition which, in the opinion of the investigator, might affect the safety of the participant or reduce the reliability of the study results 5. Involvement in any other research project where the procedures would affect the outcomes of this study.
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Study
Team
clinicalresearch@cardiov.ox.ac.uk
Jason
Chai
jason.chai@cardiov.ox.ac.uk
Prof
Robin
Choudhury
robin.choudhury@cardiov.ox.ac.uk
Prof
Robin
Choudhury
robin.choudhury@cardiov.ox.ac.uk
The study is sponsored by University of Oxford and funded by BRITISH HEART FOUNDATION .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 57713
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