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Children with acute lymphoblastic leukaemia
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Acute lymphoblastic leukemia (ALL) is a type of blood cancer where the body produces too many immature white blood cells, leading to problems with healthy blood cell production. It commonly affects children and requires treatment like chemotherapy to target and eliminate the abnormal cells.
The purpose of this study is to investigate how treatment for acute lymphoblastic leukaemia (ALL) affects the nutritional health of children. We're planning the first big study that will track changes in body composition and how much energy the body uses at rest during the entire ALL treatment in kids. We also want to figure out when sarcopenic obesity, a condition where fat increases and muscle decreases, starts to happen, and when kids start changing their eating habits in a way that makes it worse. The data we collect could help doctors give better advice on diet and lifestyle to prevent problems related to sarcopenic obesity. It's important to note that being overweight or obese can increase the chances of ALL coming back, so understanding this is crucial.
So far, past studies have missed out on measuring these things properly in children with ALL. They either used old methods or didn't look at the full picture. We want to change that by using a reliable and non-invasive method called Bioelectrical Impedance Analysis (BIA) to measure body composition. BIA measures how electricity moves through different parts of the body to estimate things like fat and muscle. We also want to measure how much energy the body uses when it's at rest, which is a big part of how much energy we use every day.
Apart from treatment, we know that lifestyle factors, like sitting too much and not being active, can make kids gain weight. Sometimes, the treatment itself can make it harder to be active. So, we're also interested in looking at ways to encourage healthier habits in kids going through this treatment, especially when they're taking dexamethasone, a medicine that can affect their eating and activity.
However, previous reviews of studies haven't given us clear answers about what works best for helping these kids. We need more well-designed trials to figure out the best ways to manage their nutrition and lifestyle. This study aims to fill that gap and hopefully make life better for children with ALL.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
You may not be able to take part if:
1. 17 years old +2. Neuro-muscular disease
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Dr
Graeme
O'Connor
+44 7958543828
Graeme.O'Connor@gosh.nhs.uk
The study is sponsored by Great Ormond Street Hospital for Children NHS Foundation Trust and funded by King Abdulaziz University.
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