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Be Part of Research - Trial Details - Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM

Completed

Open to: ALL

Age: 18.0 - 85.0

Medical Conditions

Cardiomyopathies
Cardiomyopathy, Hypertrophic
Hypertrophy


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to compare the efficacy and safety of aficamten (CK-3773274) compared with metoprolol succinate in adults with symptomatic hypertrophic cardiomyopathy and left ventricular outflow tract obstruction

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jun 2023 Feb 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Aficamten (CK-3773274) tablets administered orally

Intervention Arm Group : Aficamten up to 20 mg plus placebo for metoprolol;

Intervention Type : DRUG
Intervention Description : Placebo for aficamten (CK-3773274) administered orally

Intervention Arm Group : Metoprolol succinate up to 200 mg plus placebo for aficamten;

Intervention Type : DRUG
Intervention Description : Metoprolol succinate tablets administered orally

Intervention Arm Group : Metoprolol succinate up to 200 mg plus placebo for aficamten;

Intervention Type : DRUG
Intervention Description : Placebo for metoprolol succinate administered orally

Intervention Arm Group : Aficamten up to 20 mg plus placebo for metoprolol;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Barts Health NHS Trust
    London
  • St George's University Hospitals NHS Foundation Trust
    London
  • Royal Brompton Hospital
    London
  • Liverpool Heart and Chest Hospital NHS Foundation Trust
    Liverpool
  • Oxford University Hospital NHS Trust - John Radcliffe Hospital - OCMR
    Oxford
  • NHS Greater Glasgow and Clyde
    Glasgow


The study is sponsored by Cytokinetics and is in collaboration with Sanofi.




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Read full details for Trial ID: NCT05767346
Last updated 29 April 2025

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