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Be Part of Research - Trial Details - A Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma

A Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Carcinoma
Carcinoma, Hepatocellular


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is a Phase Ib/II, open-label, multicenter, randomized platform study to evaluate neoadjuvant immunotherapy combinations in participants with resectable HCC. The study is designed with the flexibility to open new treatment arms as new agents become available, close existing treatment arms that demonstrate minimal clinical activity or unacceptable toxicity, or modify the participant population.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2023 Sep 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Atezolizumab will be administered at a dose of 1200 mg by IV infusion on Day 1.

Intervention Arm Group : Atezo + Bev;Atezo + Bev +Tira;

Intervention Type : DRUG
Intervention Description : Bevacizumab will be administered at a dose of 15 mg/kg by IV infusion on Day 1.

Intervention Arm Group : Atezo + Bev;Atezo + Bev +Tira;Tobe + Bev;

Intervention Type : DRUG
Intervention Description : Tiragolumab will be administered at a dose of 600 mg by IV infusion on Day 1.

Intervention Arm Group : Atezo + Bev +Tira;

Intervention Type : DRUG
Intervention Description : Tobemstomig will be administered at a dose of 600 mg by IV infusion on Day 1

Intervention Arm Group : Tobe + Bev;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Imperial College London - Imperial Centre for Translational and Experimental Medicine (ICTEM)
    London
  • Belfast Health and Social Care Trust - Belfast City Hospital
    Belfast
    BT9 7AB


The study is sponsored by Hoffmann-La Roche




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Read full details for Trial ID: NCT05908786
Last updated 08 May 2025

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