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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Gillian
Radcliffe
gillier900@gmail.com
Mona
Bafadhel
mona.bafadhel@kcl.ac.uk
Madeleine
Peck
madeleine.peck2@nhs.net
Gill
Radcliffe
gill.radcliffe@nhs.net
Chronic lower respiratory diseases
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
At the King’s Centre for Lung Health we are undertaking a study to understand more about airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). We will be enrolling patients with diagnosed or suspected airways disease who are over 18 years old, as well as age matched healthy volunteers with no significant illness. All patients with airway disease will be approached during a routine respiratory clinic within the Guys and St Thomas’ NHS Foundation Trust (GSTFT). Participants will be asked if they consent to enter the study, invited at clinically relevant time points (treatment change, disease exacerbation etc.) and bronchoscopy visits. It is expected that participants will be seen no more than once per year (unless experiencing an exacerbation event). Healthy volunteers will be recruited via local advertisements. Research visits will occur at sites normally used for sample collection at King's College London and GSTFT, with all bronchoscopy visits occurring within GSTFT.
There is a desperate need to understand the body's immune pathways so we can help prevent the 700,000 UK hospital admissions every year due to lung disease symptoms. Immune pathways include the cells and molecules in your body that protect from disease and infection. Identifying these immune patterns throughout the lungs will help us understand airway disease better. We will be asking participants to carry out:
1. Disease specific questionnaires
2. Lung function tests including spirometry or oscillometry (if not performed previously within 6 months)
3. Sputum collection
4. Nasal sampling including nasosorption, nasal brushing, or nasopharyngeal swabs
5. Exhaled breath
6. Blood samples (6 tablespoons)
Optional
7. Bronchoscopy involving a flexible fibreoptic camera passed into the lungs to collect bronchoalveolar lavage, bronchosorption, bronchial brushings and bronchial biopsies.
8. To repeat these procedures at later time - expected once per year or at times of clinically relevant changes
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
Observational type: Case-controlled study;
You can take part if:
You may not be able to take part if:
Exclusion criteria for patients with airways disease or healthy volunteers: Known or suspected current pulmonary tuberculosis or HIV (human immunodeficiency virus) or Hepatitis B or C virus Surgery within the preceding 6 weeks Participants who are pregnant History of psychiatric, medical, or surgical disorders that in the opinion of the chief investigator may interfere with sample collection, undergo a bronchoscopy, or may compromise study completion or data collection Alcohol or recreational drug abuse Diagnosis of immunodeficiency requiring treatment Unable to provide written informed consent Unable to read or write English Be considered, in the opinion of the investigator, to be an unsuitable candidate for the study
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Gillian
Radcliffe
gillier900@gmail.com
Gill
Radcliffe
gill.radcliffe@nhs.net
Madeleine
Peck
madeleine.peck2@nhs.net
Mona
Bafadhel
mona.bafadhel@kcl.ac.uk
The study is sponsored by King's College London and funded by Asthma and Lung UK .
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
Read full details
for Trial ID: CPMS 58472
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
