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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

AstraZeneca Clinical Study Information Center 1-877-240-9479
information.center@astrazeneca.com


Study Location:

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Be Part of Research - Trial Details - A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors

Recruiting

Open to: FEMALE

Age: 18.0 - N/A

Medical Conditions


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This study is designed to evaluate AZD8421 alone and in combination with selected targeted anti-cancer drugs in patients with ER+HER2- advanced breast cancer, and patients with metastatic high-grade serious ovarian cancer.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2023 Jun 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : CDK2 inhibitor

Intervention Arm Group : Module 1;Module 2A_abema;Module 2A_palbo;Module 2A_ribo;

Intervention Type : DRUG
Intervention Description : SERD

Intervention Arm Group : Module 2A_abema;Module 2A_palbo;Module 2A_ribo;

Intervention Type : DRUG
Intervention Description : CDK4/6 inhibitor

Intervention Arm Group : Module 2A_ribo;

Intervention Type : DRUG
Intervention Description : CDK4/6 inhibitor

Intervention Arm Group : Module 2A_palbo;

Intervention Type : DRUG
Intervention Description : CDK4/6 inhibitor

Intervention Arm Group : Module 2A_abema;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    Manchester
    M20 4BX
  • Research Site
    London
    EC1A 7BE
  • Research Site
    Leeds
    LS9 7TF
  • Research Site
    Cambridge
    CB2 0XY

AstraZeneca Clinical Study Information Center 1-877-240-9479
information.center@astrazeneca.com



The study is sponsored by AstraZeneca




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Read full details for Trial ID: NCT06188520
Last updated 25 March 2025

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