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Be Part of Research - Trial Details - A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations

A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations

Not Recruiting

Open to: ALL

Age: 12.0 - 99.0

Medical Conditions

Advanced or Metastatic Solid Tumors


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


To evaluate the efficacy of naporafenib administered with trametinib in patients with rat sarcoma viral oncogene (RAS) Q61X solid tumors

* To evaluate the safety and tolerability of naporafenib administered with trametinib in patients with RAS Q61X solid tumors * To characterize the pharmacokinetic (PK) profile of naporafenib and trametinib when administered to patients with RAS Q61X solid tumors

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Aug 2023 Jul 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Naporafenib (ERAS-254) 200 mg twice daily (BID) of an experimental Pan-Raf inhibitor

Intervention Arm Group : Naporafenib + Trametinib;

Intervention Type : DRUG
Intervention Description : Trametinib is an FDA approved anticancer medication that targets MEK1 and MEK2.

Intervention Arm Group : Naporafenib + Trametinib;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Beatson West of Scotland Cancer Center
    Glasgow
  • Sarah Cannon Research Institute - HCA Healthcare
    City of London
    London
    W1G 6AD


The study is sponsored by Erasca, Inc.




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Read full details for Trial ID: NCT05907304
Last updated 21 May 2025

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