Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Research Activity Co-ordinator and Study Co-ordinator
None provided
nuth.projectmanagement@nhs.net


Dr Rachel Pearson
+44 (0)191 213 8466
rachel.pearson1@nhs.net


Study Location:

Find another location


Questions to ask
Skip to Main Content
English | Cymraeg
Be Part of Research - Trial Details - MRI to optimise lung cancer radiotherapy
Back

MRI to optimise lung cancer radiotherapy

Not Recruiting

Open to: All Genders

Age: Adult

Newcastle upon Tyne

Medical Conditions

Lung cancer

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Radiotherapy treatment of lung cancer aims to destroy tumour and prevent recurrence, whilst limiting radiation exposure to non-tumour regions. Many lung cancer patients have other lung diseases that result in heterogeneous function, and lung function can worsen in some people after radiotherapy as the treatment damages the few remaining lung regions with good function. The study team have developed 3D MRI scan measurements of lung function. This study aims to test their ability to report on lung functional heterogeneity in lung cancer patients and to test the ability to use this functional information to produce better radiotherapy treatment strategies that limit radiation impact on post-treatment lung function.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Dec 2023 14 Jun 2024

The study team are a group of researchers examining the feasibility of measuring lung function using Magnetic Resonance Imaging (MRI scanning) to develop new ways of planning radiotherapy treatment for lung cancer. The research uses a special tracer gas that can be seen on MRI scans and can be safely inhaled during MRI scanning. The MRI scans give pictures of this tracer gas in the lungs and show any regions of the lungs that are not working well (i.e. are poorly ventilated). MRI scanning is used because it is a safe medical imaging method that can be performed without risking harm to the patient. There are other medical imaging techniques used to assess lung function, like CT scanning and gamma camera methods. However, these other methods use X-rays or radioactivity to produce images of lung function, which can harm patients. The motivation for this work is to develop lung imaging techniques that do not involve radioactivity or X-rays. In this study, the team are assessing if it is possible to use our MRI scan methods to detect parts of the lung that are poorly ventilated in patients with lung cancer who are planning to receive radiotherapy and test how well our scans can characterise differences in function in different areas of the lung.


Adults over 18 years old, with non-small cell lung cancer and planned to receive radical OR high dose palliative radiotherapy (+/- adjuvant chemotherapy or surgery).

You can take part if:



You may not be able to take part if:


1. Patients below the age of 18 years 2. Patients who are not able or decline to give informed consent to participate in the study 3. Non-English speakers4. Body habitus incompatible with positioning within the MRI scanner sensor used for 19F-MRI (approximately equivalent to a body circumference > 120cm at chest height, and body mass index > 35 kg/m²) 5. Pregnant or breastfeeding 6. MRI contraindications: incompatible implanted medical device (e.g. cardiac pacemaker), or metallic implants incompatible with MRI 7. Claustrophobia incompatible with MRI


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Freeman Hospital
    Freeman Road High Heaton
    Newcastle upon Tyne
    NE7 7DN

This study will not benefit patients directly, but the information that is obtained may help in the development of new non-invasive methods to study lung function and detect differences in lung function within the lungs of patients with lung cancer requiring radiotherapy. It is anticipated that this will be of benefit in the future to patients who are having radiotherapy.

Dr Research Activity Co-ordinator and Study Co-ordinator
None provided
nuth.projectmanagement@nhs.net


Dr Rachel Pearson
+44 (0)191 213 8466
rachel.pearson1@nhs.net



The study is sponsored by Newcastle upon Tyne Hospitals NHS Foundation Trust and funded by Medical Research Council.



We'd like your feedback

Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.


Is this study information helpful?

What will you do next?
Read full details for Trial ID: ISRCTN10891735

Or CPMS 58734

Last updated 09 January 2024

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

Back to the top