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Be Part of Research - Trial Details - A Clinical Study of V940 Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

A Clinical Study of V940 Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)


Open to: All Genders

Age: 18 Years - N/A

Medical Conditions


This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.

The purpose of this study is to learn if V940 which is an individualized neoantigen therapy (INT; formerly, called messenger ribonucleic acid [mRNA]-4157) with pembrolizumab (MK-3475) is safe and prevents cancer from returning in people with high-risk melanoma. Researchers want to know if V940 with pembrolizumab is better than receiving pembrolizumab alone at preventing the cancer from returning.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jul 2023 Oct 2029


Intervention Type : Biological
Intervention Description : IM injection

Intervention Arm Group : V940 + Pembrolizumab

Intervention Type : Biological
Intervention Description : IV infusion

Intervention Arm Group : Placebo + Pembrolizumab;V940 + Pembrolizumab

Intervention Type : Other
Intervention Description : IM injection

Intervention Arm Group : Placebo + Pembrolizumab

You can take part if:

You may not be able to take part if:

This is in the inclusion criteria above

Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University College London Hospital ( Site 1807)
    London, City Of
    NW1 2PG
  • Norfolk and Norwich University Hospitals NHS Foundation Trust ( Site 1813)
    NR4 7UY
    Kensington And Chelsea
    SW3 6JJ
  • Bristol Haematology and Oncology Centre ( Site 1811)
    Bristol, City Of
    BS2 8ED
  • Addenbrooke's Hospital ( Site 1800)
    CB2 2QQ
  • The Churchill Hospital ( Site 1805)
    OX3 7LE
  • Western General Hospital ( Site 1806)
    EH4 2XU
  • The Christie NHS Foundation Trust ( Site 1814)
    m20 4bx

The study is sponsored by Merck Sharp & Dohme LLC and funded by ModernaTX, Inc..

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Read full details for Trial ID: NCT05933577
Last updated 23 April 2024

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