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Be Part of Research - Trial Details - Study of ARO-C3 in Adult Healthy Volunteers and Patients With Complement Mediated Renal Disease

Study of ARO-C3 in Adult Healthy Volunteers and Patients With Complement Mediated Renal Disease

Not Recruiting

Open to: ALL

Age: 18.0 - 70.0

Medical Conditions

Glomerulonephritis, IGA


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of AROC3-1001 is to evaluate the safety, tolerability, pharmacokinetics and/or pharmacodynamics in adult healthy volunteers (HVs) and in adult patients with complement-mediated renal disease (C3 Glomerulopathy \[C3G\] and IgA Nephropathy \[IgAN\]). In Part 1 of the study, HVs will receive either one or two doses of ARO-C3 or placebo. In Part 2 of the study, adult patients with C3G/IgAN will receive 3 open-label doses of ARO-C3. Dose levels in Part 2 will be determined based on cumulative safety and pharmacodynamic data from Part 1.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2022 May 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : ARO-C3 for sc injection

Intervention Arm Group : ARO-C3 (Adult Patients with C3G or IgAN);ARO-C3 (Healthy Volunteers);

Intervention Type : DRUG
Intervention Description : sterile normal saline (0.9% NaCl) for sc injection

Intervention Arm Group : Placebo (Healthy Volunteers);



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site 1
    Leicester
    LE1 SWW
  • Research Site 4
    Oxford
    OX3 7LE
  • Research Site 6
    Newcastle
    NE7 7DN


The study is sponsored by Arrowhead Pharmaceuticals




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Read full details for Trial ID: NCT05083364
Last updated 23 March 2025

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