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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Molar Hypomineralization Dental Enamel Hypoplasia
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Background/study aim:
Molar incisor hypomineralisation (MIH) is a common disorder of tooth development. Affected teeth have weak enamel and adult molars often require extensive treatment or even extraction. A preliminary study, carried out in Sheffield Dental Hospital, discovered that 12% of MIH children also had congenitally missing adult teeth, presenting further challenges to treatment-planning. This novel finding stimulated discussion between international MIH expertsÍľ whilst some clinicians had observed this association, others had not. Therefore the primary aim of this international study is to determine the association between MIH and missing teeth in different populations. This has important clinical and biological relevance in understanding the presentation and management of MIH.
Participants/research sites:
This study will include 584 children with MIH and a comparison group of 584 children without MIH. Young dental patients, aged 7-16 years, who attend for a check-up or treatment at one of the 15 participating countries will be invited to take part. The UK sites are Sheffield, Newcastle and University College London Dental Hospitals and all children will be seen by specialists/consultants in paediatric dentistry to confirm their diagnosis of MIH. The main inclusion criteria is that children have a dental xray as part of their routine care.
Data collection:
Following a routine dental check-up we will grade the severity of the participants' MIH (if present) and record any other dental anomalies (e.g. abnormal tooth number, position or shape). We will also check the dental xray for other anomalies that cannot be seen from the clinical exam. We will analyse the prevalence of MIH and association with other dental anomalies to see if there are difference according to sex or ethnicity and compare our findings with the non-MIH group. We anticipate the study will take 18 months.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
"Walshaw EG, Noble F, Conville R, Anne Lawson J, Hasmun N, Rodd H. Molar incisor hypomineralisation and dental anomalies: A random or real association? Int J Paediatr Dent. 2020 May;30(3):342-348. doi: 10.1111/ipd.12601. Epub 2019 Dec 13."; "31790155"; "Baccetti T. A controlled study of associated dental anomalies. Angle Orthod. 1998 Jun;68(3):267-74. doi: 10.1043/0003-3219(1998)0682.3.CO;2."; "9622764"; "Brook AH. Variables and criteria in prevalence studies of dental anomalies of number, form and size. Community Dent Oral Epidemiol. 1975 Nov;3(6):288-93. doi: 10.1111/j.1600-0528.1975.tb00326.x."; "1104248"; "Ghanim A, Silva MJ, Elfrink MEC, Lygidakis NA, Marino RJ, Weerheijm KL, Manton DJ. Molar incisor hypomineralisation (MIH) training manual for clinical field surveys and practice. Eur Arch Paediatr Dent. 2017 Aug;18(4):225-242. doi: 10.1007/s40368-017-0293-9. Epub 2017 Jul 18."; "28721667"; "Schwendicke F, Elhennawy K, Reda S, Bekes K, Manton DJ, Krois J. Global burden of molar incisor hypomineralization. J Dent. 2018 Jan;68:10-18. doi: 10.1016/j.jdent.2017.12.002. Epub 2017 Dec 6. Erratum In: J Dent. 2019 Jan;80:89-92. doi: 10.1016/j.jdent.2018.11.006."; "29221956"
You can take part if:
You may not be able to take part if:
This is in the inclusion criteria above
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
The study is sponsored by Sheffield Teaching Hospitals NHS Foundation Trust
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You can print or share the study information with your GP/healthcare provider or contact the research team directly.
