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Be Part of Research - Trial Details - A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Carcinoma
Carcinoma, Renal Cell


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to assess the efficacy and safety of oral belzutifan (MK-6482) plus intravenous (IV) pembrolizumab (MK-3475) compared to placebo plus pembrolizumab, in the adjuvant treatment of Clear Cell Renal Cell Carcinoma (ccRCC) post nephrectomy.

The primary study hypothesis is that belzutifan plus pembrolizumab is superior to placebo plus pembrolizumab with respect to disease-free survival (DFS).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Mar 2022 Oct 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Three 40 mg tablets given as a single oral 120 mg dose.

Intervention Arm Group : Belzutifan + Pembrolizumab;

Intervention Type : BIOLOGICAL
Intervention Description : 400 mg via IV infusion

Intervention Arm Group : Belzutifan + Pembrolizumab;Placebo + Pembrolizumab;

Intervention Type : DRUG
Intervention Description : Oral tablet

Intervention Arm Group : Placebo + Pembrolizumab;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Royal Free Hospital ( Site 3304)
    London
    England
    NW32QG
  • The Christie NHS Foundation Trust ( Site 3301)
    Manchester
    England
    M20 4BX
  • City Hospital, Nottingham University Hospitals ( Site 3303)
    Nottingham
    England
    NG5 1PF
  • Beatson West of Scotland Cancer Centre-Clinical Trials Unit ( Site 3305)
    Glasgow
    Glasgow City
    G12 0YN
  • Charing Cross Hospital ( Site 3302)
    London
    Hammersmith And Fulham
    W6 8RF
  • St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 3307)
    London
    London, City Of
    EC1A 7BE
  • Singleton Hospital ( Site 3306)
    Swansea
    Wales
    SA2 8QA


The study is sponsored by Merck Sharp & Dohme LLC




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Read full details for Trial ID: NCT05239728
Last updated 14 November 2024

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