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Be Part of Research - Trial Details - A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Lymphoma
Leukemia
Leukemia, Lymphoid
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, B-Cell


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to compare the efficacy and safety of pirtobruitinib (LOXO-305) to ibrutinib in participants with CLL/SLL. Participants may or may not have already had treatment for their cancer. Participation could last up to six years.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jul 2022 Jun 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Administered orally.

Intervention Arm Group : Pirtobrutinib;

Intervention Type : DRUG
Intervention Description : Administered orally.

Intervention Arm Group : Ibrutinib;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Leicester Royal Infirmary
    Leicester
    Leicestershire
    LE1 5WW
  • Bristol Haematology and Oncology Centre
    Bristol
    Bristol, City Of
    BS2 8ED
  • Castle Hill Hospital
    Hull
    East Riding Of Yorkshire
    HU16 5JQ
  • St Bartholomew's Hospital
    London
    London, City Of
    EC1A 7BE
  • Singleton Hospital
    Swansea
    SA2 8QA


The study is sponsored by Loxo Oncology, Inc. and is in collaboration with Eli Lilly and Company.




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Read full details for Trial ID: NCT05254743
Last updated 17 April 2025

This page is to help you find out about a research study and if you may be able to take part

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