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Be Part of Research - Trial Details - Study of Magrolimab Combination Therapy in Patients With Non-Surgically Removable Locally Advanced or Metastatic Triple-Negative Breast Cancer

Study of Magrolimab Combination Therapy in Patients With Non-Surgically Removable Locally Advanced or Metastatic Triple-Negative Breast Cancer

Stopped

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Breast Neoplasms
Triple Negative Breast Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The goals of this clinical study are to learn about the safety, tolerability, dosing and effectiveness of magrolimab in combination with nab-paclitaxel or paclitaxel (cohort 1) or with sacituzumab govitecan-hziy (cohort 2) in patients with non-surgically removable locally advanced or metastatic triple-negative breast cancer.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2021 Oct 2024

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Administered intravenously

Intervention Arm Group : Phase 2 Cohort 1 Arm A: Magrolimab + Nab-Paclitaxel or Paclitaxel;Phase 2 Cohort 1 Arm B: Nab-Paclitaxel or Paclitaxel;Phase 2 Cohort 2: Magrolimab + Sacituzumab govitecan;Safety Run-in Cohort 1: Magrolimab + Nab-Paclitaxel or Paclitaxel;Safety Run-in Cohort 2: Magrolimab + Sacituzumab govitecan;

Intervention Type : DRUG
Intervention Description : Administered intravenously

Intervention Arm Group : Phase 2 Cohort 1 Arm A: Magrolimab + Nab-Paclitaxel or Paclitaxel;Phase 2 Cohort 1 Arm B: Nab-Paclitaxel or Paclitaxel;Safety Run-in Cohort 1: Magrolimab + Nab-Paclitaxel or Paclitaxel;

Intervention Type : DRUG
Intervention Description : Administered intravenously

Intervention Arm Group : Phase 2 Cohort 1 Arm A: Magrolimab + Nab-Paclitaxel or Paclitaxel;Phase 2 Cohort 1 Arm B: Nab-Paclitaxel or Paclitaxel;Safety Run-in Cohort 1: Magrolimab + Nab-Paclitaxel or Paclitaxel;

Intervention Type : DRUG
Intervention Description : Administered intravenously

Intervention Arm Group : Phase 2 Cohort 2: Magrolimab + Sacituzumab govitecan;Safety Run-in Cohort 2: Magrolimab + Sacituzumab govitecan;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University College London
    London
    WC1E 6BT
  • University Hospitals of Leicester NHS Trust
    Leicester
    LE1 5WW
  • The Christie NHS Foundation Trust
    Manchester
    M20 4BX


The study is sponsored by Gilead Sciences




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Read full details for Trial ID: NCT04958785
Last updated 21 October 2024

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