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Be Part of Research - Trial Details - CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)

CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)

Medical Conditions

Oropharyngeal Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


CompARE is a multicentre, phase III open-label randomised controlled trial using an adaptive, Multi-Arm, Multi-Stage (MAMS) design.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jul 2015 Dec 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Arm Group : Arm 1 (control): chemoradiotherapy;Arm 5: Durvalumab + Arm 1;

Intervention Type : DRUG
Intervention Arm Group : Arm 5: Durvalumab + Arm 1;

Intervention Type : PROCEDURE
Intervention Arm Group : Arm 1 (control): chemoradiotherapy;Arm 5: Durvalumab + Arm 1;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Belfast City Hospital
    Belfast
    BT9 7AB
  • Nottingham City Hospital
    Nottingham
    NG5 1PB
  • Musgrove Park Hospital
    Taunton
    TA1 5DA
  • Western General Hospital
    Edinburgh
    EH4 2XU
  • Norfolk and Norwich University Hospital
    Norwich
    NR4 7UY
  • Royal United Hospital
    Bath
    BA1 3NG
  • Aberdeen Royal Infirmary
    Aberdeen
    AB25 2ZN
  • Christie Hospital
    Manchester
    M20 4BX
  • Velindre Cancer Centre
    Cardiff
    CF14 2TL
  • Cheltenham General Hospital
    Cheltenham
    GL53 7AN
  • Torbay Hospital
    Torquay
    TQ2 7AA
  • Aintree University Hospital
    Liverpool
    L9 7AL
  • Clatterbridge Cancer Centre
    Wirral
    CH63 4JY
  • North Middlesex Hospital
    London
    N18 1QX
  • Royal Shrewsbury Hospital
    Shrewsbury
    SY3 8XQ
  • Royal Preston Hospital
    Preston
    Lancashire
    PR2 9HT
  • Queen's Hospital
    Romford
    Essex
    RM7 0AG
  • Freeman Hospital
    Newcastle Upon Tyne
    Tyne And Wear
    NE7 7DN
  • Castle Hill Hospital
    Cottingham
    East Yorkshire
    HU16 5JQ
  • Derriford Hospital
    Plymouth
  • St James's University Hospital
    Leeds
    West Yorkshire
    LS9 7TF
  • Colchester General Hospital
    Colchester
    Essex
    CO4 5JL
  • Churchill Hospital
    Oxford
    Oxfordshire
    OX3 7LE
  • University Hospital Coventry
    Coventry
    West Midlands
    CV2 2DX
  • Queen Elizabeth Hospital
    Birmingham
    West Midlands
    B15 2TH
  • Bradford Royal Infirmary
    Bradford
    West Yorkshire
    BD9 6RJ
  • Royal Devon and Exeter Hospital
    Exeter
    Devon
    EX2 5DW
  • James Cook University Hospital
    Middlesbrough
    North Yorkshire
    TS4 3BW
  • Weston Park Hospital
    Sheffield
    South Yorkshire
    S10 2SJ
  • Leicester Royal Infirmary
    Leicester
    East Midlands
    LE1 5WW
  • York Hospital
    York
    North Yorkshire
    YO31 8HE
  • Newcross Hospital
    Wolverhampton
    West Midlands
    WV10 OQP
  • Bristol Haematology and Oncology Centre
    Bristol
    BS2 8ED
  • Addenbrooke's Hospital
    Cambridge
    CB2 0QQ
  • Beatson West of Scotland Cancer Centre
    Glasgow
    G12 0YN
  • Singleton Hospital
    Swansea
    SA2 8QA


The study is sponsored by University of Birmingham and is in collaboration with AstraZeneca; Cancer Trials Ireland.




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Read full details for Trial ID: NCT04116047
Last updated 26 July 2024

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