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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Christian Becker
01865740468
christian.becker@wrh.ox.ac.uk


Study Location:

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Be Part of Research - Trial Details - FENOX: Fibroids and Endometriosis Study Oxford – A Study into the Biology of Uterine Fibroids and Endometriosis.
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FENOX: Fibroids and Endometriosis Study Oxford – A Study into the Biology of Uterine Fibroids and Endometriosis.

Recruiting

Open to: Female

Age: Adult

Oxford

Medical Conditions

Endometriosis, uterine fibroids.

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Millions of women suffer from the consequences of endometriosis and uterine fibroids. These include severe pain, abnormal uterine bleeding, infertility and miscarriages. Current treatment is associated with significant side effects and risks.To better understand the underlying mechanisms of these conditions, this prospective study will use biological samples such as blood, saliva, urine, peritoneal fluid and endometrial or fibroid tissue in state-of-the-art biomedical assays together with detailed clinical and intraoperative data from participants.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Apr 2018 30 Sep 2025

Once consented, participants complete detailed questionnaires at baseline and then at intervals (6-8 weeks, 6 months, 1 year and yearly, for a total of 5 years) about their symptoms, medications, co-morbidities, and ethnicity. Consenting women will also be asked to donate biological samples such as blood, urine and saliva at baseline and again at a follow-up visit after their surgery, in addition to tissue taken at time of surgery. We will then analyse the differences in tissue and clinical data between patient groups to understand the conditions better, and to identify new ways of treatment.


Women of reproductive age (18 years until menopause) who are planned to undergo surgery for endometriosis and/or fibroid-associated symptoms, or unrelated gynaecological surgery, will be invited to participate.

You can take part if:



You may not be able to take part if:


The participant may not enter the study if ANY of the following apply:1.Women who are pregnant.2.Women who are unable to read, or to understand written or spoken English.3.History of cancer/ diagnosis of current cancer.


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Oxford University Hospitals Trust, Women's Centre
    John Radcliffe Hospital, Oxford OX3 9DU
    Oxford
    OX3 9DU

There are no direct benefits for participants in the study, and there will be no payments made to study participants. The endometrial sampling procedure carries a small additional risk of minor bleeding, uterine perforation (<1%) and an extension to the length of the surgery by 5 minutes.

Prof Christian Becker
01865740468
christian.becker@wrh.ox.ac.uk



The study is sponsored by University of Oxford, Clinical Trials and Research Governance Team and funded by Nuffield Department of Women's and Reproductive Health, University of Oxford.



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Read full details for Trial ID: ISRCTN13560263
Last updated 18 March 2024

This page is to help you find out about a research study and if you may be able to take part

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