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Contact Information:

Edoardo R. de Natale, MD MSc Ph.D 07503741242
e.de-natale@exeter.ac.uk


Heather Wilson, MSc Ph.D h.wilson4@exeter.ac.uk


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Be Part of Research - Trial Details - Synaptic Loss in Multiple System Atrophy
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Synaptic Loss in Multiple System Atrophy

Recruiting

Open to: ALL

Age: 45.0 - 80.0

Exeter

Medical Conditions

Multiple System Atrophy
Progressive Supranuclear Palsy (PSP)

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


In this study the investigators would like to investigate the degree of damage of the synapses, an important part of the neurons vital for the communications between neurons, in Multiple System Atrophy (MSA), and pathology related to abnormal accumulation of a protein named tau, in Progressive Supranuclear Palsy (PSP).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2021 Mar 2027

OBSERVATIONAL

Intervention Type : OTHER
Intervention Description : The group of MSA patients will undergo a collection of demographic data, a neurological examination with administration of clinical scales relevant for MSA, and a collection of venous blood sample for routine and biomarker analyses.

Participants will undergo one PET scan with the tracer \[11C\]UCB-J, and one PET scan with the tracer \[18F\]FDG. All participants will also undergo one MRI scan.

Participants will also undergo one lumbar puncture (optional).

All procedures will be performed at baseline and after one-year follow-up.

A subgroup of patients with MSA will also undergo, at one time point only, one PET scan with the tracer \[18F\]APN107.

Intervention Arm Group : Patients with MSA;

Intervention Type : OTHER
Intervention Description : The group of PSP patients will undergo a collection of demographic data, a neurological examination with administration of clinical scales relevant for PSP, and a collection of venous blood sample for routine and biomarker analyses. Participants will undergo one PET scan with the tracer \[18F\]APN107 and one MRI scan. All procedures will be performed at baseline and after one-year follow-up.

Intervention Arm Group : Patients with Progressive Supranuclear Palsy;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University of Exeter
    Exeter
    SE16 7RJ

Heather Wilson, MSc Ph.D h.wilson4@exeter.ac.uk


Edoardo R. de Natale, MD MSc Ph.D 07503741242
e.de-natale@exeter.ac.uk



The study is sponsored by University of Exeter



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Read full details for Trial ID: NCT05121012
Last updated 06 February 2026

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