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Contact Information:

Edoardo R. de Natale, MD MSc Ph.D 07503741242
e.de-natale@exeter.ac.uk


Heather Wilson, MSc Ph.D h.wilson4@exeter.ac.uk


Study Location:

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Be Part of Research - Trial Details - Synaptic Loss in Multiple System Atrophy

Synaptic Loss in Multiple System Atrophy

Recruiting

Open to: ALL

Age: 45.0 - 70.0

Medical Conditions

Multiple System Atrophy
Shy-Drager Syndrome
Atrophy


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


In this study the investigators would like to investigate the degree of damage of the synapses, an important part of the neurons vital for the communications between neurons, in Multiple System Atrophy (MSA).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Sep 2021 Apr 2025

OBSERVATIONAL

Intervention Type : OTHER
Intervention Description : All participants will undergo a collection of demographic data, a neurological examination and administration of clinical scales relevant for MSA-P. All participants will undergo a collection of venous blood sample for routine analyses.

Participants will undergo one PET scan with the tracer \[11C\]UCB-J, and one PET scan with the tracer \[18F\]FDG. All participants will also undergo one MRI scan.

Participants will also undergo one lumbar puncture (optional).

All procedures will be performed at baseline and after one-year follow-up.

Intervention Arm Group : Group 1;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University of Exeter
    Exeter
    SE16 7RJ

Edoardo R. de Natale, MD MSc Ph.D 07503741242
e.de-natale@exeter.ac.uk


Heather Wilson, MSc Ph.D h.wilson4@exeter.ac.uk



The study is sponsored by University of Exeter




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Read full details for Trial ID: NCT05121012
Last updated 05 December 2024

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