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Be Part of Research - Trial Details - The Effect of Lycopene on Sperm Quality in Men Attending Fertility Clinic

The Effect of Lycopene on Sperm Quality in Men Attending Fertility Clinic

Completed

Open to: MALE

Age: 18.0 - 50.0

Medical Conditions

Total Motile Sperm Count


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The goal of this clinical trial is to test whether lycopene (an antioxidant found in cooked tomatoes) will improve the number of swimming sperm in the ejaculates of men with low total motile sperm count.

Participants will take either lycopene capsules or identical capsules containing no lycopene for 12 weeks. We will analyse the quality of their semen before and after taking the capsules, and compare the results.

Hypothesis: Supplementation with lycopene will improve testicular function (semen quality) in males with low total motile sperm count (TMSC).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

May 2023 Dec 2025

INTERVENTIONAL

Intervention Type : DIETARY_SUPPLEMENT
Intervention Description : Capsule containing lycopene 7mg x 2 daily for 12 weeks

Intervention Arm Group : Lycopene;

Intervention Type : DIETARY_SUPPLEMENT
Intervention Description : Capsule containing inactive substance 7mg x 2 daily for 12 weeks

Intervention Arm Group : Placebo;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Jessop Fertility
    Sheffield


The study is sponsored by Sheffield Teaching Hospitals NHS Foundation Trust and is in collaboration with Health Education England, Wessex; Manchester Metropolitan University; University of Sheffield.




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Read full details for Trial ID: NCT05671562
Last updated 02 February 2026

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