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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.
Joshua Caddy
023 8120 5537
j.caddy@soton.ac.uk
Nicole Keyworth
023 8120 3785
n.e.keyworth@soton.ac.uk
Lymphoma Lymphoma, B-Cell Lymphoma, Large B-Cell, Diffuse
This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.
This study evaluates the addition of Acalabrutinib to current standard therapy of Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone (R-CHOP) for patients with previously untreated CD20 positive Diffuse Large B-cell Lymphoma (DLBCL) requiring full course chemoimmunotherapy.
All patients will receive one cycle of R-CHOP. Two thirds of patients (Arm B) will go on to receive a further 5 cycles (every 21 days) of R-CHOP with Acalabrutinib. Acalabrutinib will be taken orally twice daily continuously in 21 day cycles.
One third of patients (Arm A) will continue with 5 cycles of R-CHOP.
Patients will be followed up initially for 24 months and then for disease status and survival until 114 progression events have been observed.
Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.
The recruitment start and end dates are as follows:
You can take part if:
You may not be able to take part if:
This is in the inclusion criteria above
Below are the locations for where you can take part in the trial. Please note that not all sites may be open.
Joshua Caddy
023 8120 5537
j.caddy@soton.ac.uk
Nicole Keyworth
023 8120 3785
n.e.keyworth@soton.ac.uk
The study is sponsored by University Hospital Southampton NHS Foundation Trust and is in collaboration with AstraZeneca.
Your feedback is important to us. It will help us improve the quality of the study information on this site. Please answer both questions.
You can print or share the study information with your GP/healthcare provider or contact the research team directly.
