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Be Part of Research - Trial Details - Hypothermia for Cardiac Arrest in Paediatrics
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Hypothermia for Cardiac Arrest in Paediatrics

Completed

Open to: ALL

Age: 0.0027397260273972603 - 17.0

London

Medical Conditions

Heart Arrest
Hypothermia

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The investigators hypothesized that, following cardiac arrest in pediatric patients, hypothermia therapy will improve the proportion of patients with a good functional outcome compared to a normothermic control group.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jan 2005 Sep 2009

INTERVENTIONAL

Intervention Type : OTHER
Intervention Description : Patients randomized to the Normothermia arm (esophageal temp 36.5-37.5 ÂşC) were maintained at an esophageal temperature of 36.5-37.5ÂşC for 48 hours. Patients who were hypothermic (temperature \< 35 ÂşC) when randomized to the normothermia group were rewarmed slowly using the servo-controlled mattress. Patients who were hyperthermic following randomization to the normothermia group were actively cooled to normothermia using the servo-controlled mattress. Neuromuscular blockers were administered as needed intravenously in both groups of patients to prevent shivering.

Intervention Arm Group : 1;

Intervention Type : OTHER
Intervention Description : Patients randomized to the Hypothermia arm (esophageal temp 33º to 34 °C) were cooled rapidly using the cooling protocol developed for the Hypothermia Paediatric Head Injury Trial. A temperature probe was placed in the esophagus and its position confirmed using a chest radiograph. Patients were placed on a servo-controlled cooling blanket and covered in crushed ice (in sealed plastic bags covered by pillow cases) and a second cooling blanket. Once the esophageal temperature reached 34.0ºC, the ice and second cooling blanket was removed and esophageal temperature was maintained at 33º to 34 °C for 48 hours using the servo-controlled cooling mattress. Patients treated with ECMO were cooled using the extracorporeal circuit cooling-device. Rewarming was done at a rate of 0.5 ºC every 2 hours until an esophageal temperature of 36.5 ºC was reached. Thereafter temperature was recorded but not controlled by surface cooling.

Intervention Arm Group : 2;



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This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Great Ormond Street Hospital
    London


The study is sponsored by The Hospital for Sick Children



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Read full details for Trial ID: NCT00754481
Last updated 08 July 2021

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