Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Mrs Sophie Varkonyi-Clifford
+44 (0)2381 550206
coat@soton.ac.uk


Prof Nick Francis
+44 (0)23 8059 1778
nick.francis@soton.ac.uk


More information about this study, what is involved and how to take part can be found on the study website.

Study Location:

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Be Part of Research - Trial Details - Cellulitis optimal antibiotic treatment

Cellulitis optimal antibiotic treatment

Recruiting

Open to: All Genders

Age: Adult

Medical Conditions

Cellulitis


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Cellulitis is a deep infection of the skin and subcutaneous tissues and most often occurs in the legs. It is a painful condition that is associated with inflammation and swelling of the site, and often systemic symptoms such as fever, headache, muscle aches, malaise, and fatigue. Patients report feeling unwell and that it has a significant impact on their mobility and ability to carry out their usual activities. NICE guidelines recommend oral flucloxacillin 500–1000 mg four times daily for 5-7 days as first-line treatment for most patients with cellulitis in the community, but most prescriptions are dispensed for a 7-day course. We will be assessing the effectiveness and safety of a 5-day treatment versus the standard 7-day treatment. We also aim to evaluate the cost-consequences of a shorter course from an NHS and personal perspective.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

18 Aug 2023 30 Oct 2025

Participants will be randomly allocated to one of two groups. In addition to usual care, participants will either be assigned to a 5-day oral flucloxacillin course or the standard 7-day flucloxacillin course. Participants prescribed a 5-day course of oral flucloxacillin, will be posted two additional days’ worth of medication (8 capsules in total for two days), which will either be the antibiotic or placebo capsules. Participants will be asked to fill out daily questionnaires and express their experiences with their cellulitis and taking part in the trial.


Adults presenting in primary care with unilateral cellulitis of the leg

You can take part if:



You may not be able to take part if:


1. Penicillin allergy 2. Bilateral cellulitis3. Antibiotics for cellulitis within the past month4. Post-operative cellulitis (within 30 days of operative procedures on the same leg)5. Cellulitis resulting from human/animal bite injury6. Cellulitis associated with chronic (>6 weeks) leg ulceration7. Require immediate hospital admission or out-patient intravenous antibiotic therapy


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • CRN Wessex
    Berrywood Business Village Hedge End
    Southampton
    SO30 2UN
  • CRN East of England
    20 Rouen Road
    Norwich
    NR1 1QQ
  • CRN NWC
    Liverpool Science Park, Innovation Centre 1, 131 Mount Pleasant
    Liverpool
    L3 5TF
  • CRN SWP
    Bowmoor House, Royal Devon and Exeter Hospital (Wonford)
    Exeter
    EX2 5DW
  • CRN WoE
    Whitefriars, Lewins Mead
    Bristol
    BS1 2NT
  • CRN Yorkshire & Humber
    21 Queen St
    Leeds
    LS1 2TW
  • CRN Thames Valley and South Midlands
    Unipart House, NIHR CRN: Thames Valley and South Midlands Offices Level 2 West, Garsington Rd
    Oxford
    OX4 6PG
  • CRN North London
    20 Churchill Place Canary Wharf
    London
    E14 5HJ

Benefits include that participants may see an improvement in their cellulitis and avoid needing to use antibiotics or for longer than is necessary. participants will be helping to further our knowledge of how to treat patients with cellulitis and this will benefit others with the same condition in the future. However, possible risks include the listed side effects of oral flucloxacillin, risks to the participant's child if they were to become pregnant at any point during the trial, and the need to attend a clinic visit and fill out questionnaires that would not normally be asked of them if they were not part of the trial.

Prof Nick Francis
+44 (0)23 8059 1778
nick.francis@soton.ac.uk


Mrs Sophie Varkonyi-Clifford
+44 (0)2381 550206
coat@soton.ac.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by University of Southampton and funded by Health Technology Assessment Programme.




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Read full details for Trial ID: ISRCTN27053187

Or CPMS 54167

Last updated 08 April 2025

This page is to help you find out about a research study and if you may be able to take part

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