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Contact Information:

Stemline Trials 1-877-332-7961
clinicaltrials@menarinistemline.com


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Be Part of Research - Trial Details - Study of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to ER+/HER-2- Breast Cancer

Study of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to ER+/HER-2- Breast Cancer

Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Neoplasms
Brain Neoplasms
Breast Neoplasms
Neoplasms by Site
Nervous System Neoplasms
Central Nervous System Neoplasms
Nervous System Diseases
Brain Diseases
Central Nervous System Diseases
Breast Diseases


This information is provided directly by researchers and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information.


This is a multi-site, global, open-label study that includes a phase 1b evaluation of elacestrant in combination with abemaciclib in women and men with brain metastases from estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER-2) negative breast cancer. Phase 1b was designed to select the recommended phase 2 dose and is followed by an ongoing phase 2 evaluation of elacestrant in combination with abemaciclib in patients with active brain metastases from ER-positive, HER-2 negative breast cancer.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Aug 2022 Dec 2025

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : 300 mg, 400 mg

Intervention Arm Group : Phase 1b Cohort 1;Phase 1b Cohort 2;Phase 1b Cohort 3;Phase 2;

Intervention Type : DRUG
Intervention Description : 100 mg, 150 mg

Intervention Arm Group : Phase 1b Cohort 1;Phase 1b Cohort 2;Phase 1b Cohort 3;Phase 2;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Guy's and St Thomas' NHS Foundation Trust
    London
  • The Clatterbridge Cancer Centre NHS Foundation Trust
    Liverpool
  • The Christie NHS Foundation Trust - Medical Oncology
    Manchester
    M20 4BX
  • University College London Hospitals NHS Foundation Trust - University College Hospital (UCH) - Macmillan Cancer Centre
    London
  • University Hosiptals of Leicester NHS Trust -Glenfield Hospital
    Leicester


The study is sponsored by Stemline Therapeutics, Inc.




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Read full details for Trial ID: NCT05386108
Last updated 18 November 2024

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.