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Be Part of Research - Trial Details - Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)

Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (firmMIND)

Not Recruiting

Open to: ALL

Age: 18.0 - 99.0

Medical Conditions

Lymphoma
Lymphoma, B-Cell
Lymphoma, Large B-Cell, Diffuse


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to assess the efficacy and safety of of tafasitamab plus lenalidomide in adults with diffuse large B-cell lymphoma (DLBCL) who have relapsed or are refractory to at least 1 but no more than 3 previous systemic DLBCL treatment regimens and who are not eligible for high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2022 Apr 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Tafasitamab will be administered intravenously in 28-day cycles. During Cycles 1 through 3, tafasitamab will be administered weekly on Days 1, 8, 15, and 22; an additional loading dose will be administered on Cycle 1 Day 4. Starting with Cycle 4, tafasitamab will be administered on Days 1 and 15 of each cycle.

Intervention Arm Group : Tafasitamab and Lenalidomide;

Intervention Type : DRUG
Intervention Description : Participants will self-administer lenalidomide capsules orally on Days 1-21 of each 28-day cycle, up to 12 cycles.

Intervention Arm Group : Tafasitamab and Lenalidomide;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Antrim Area Hospital Northern Health Social Care Trust
    Antrim
    BT41 2RL
  • Belfast Health and Social Care Trust, of Trust Headquarters
    Belfast
    BT9 7AB


The study is sponsored by Incyte Corporation




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Read full details for Trial ID: NCT05429268
Last updated 03 July 2025

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