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Contact Information:

Heather Wilson, MSc Ph.D 07889950086
h.wilson4@exeter.ac.uk


Edoardo R. de Natale, MD MSc Ph.D 07503741242
e.de-natale@exeter.ac.uk


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Be Part of Research - Trial Details - Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR
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Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR

Recruiting

Open to: ALL

Age: 50.0 - 85.0

Exeter

Medical Conditions

Parkinson Disease
Neurodegenerative Diseases

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


It is not known what causes Parkinson's disease and what makes it worsen over time. Research conducted in the past few years has highlighted the possible role of inflammation on this process but its actual mechanisms are still obscure.

In this study, the investigators aim to gain understanding on how inflammation is increased in Parkinson's disease and what are its mechanisms, by performing two Positron Emission Tomography (PET) scans using the tracer \[11C\]PBR28, that takes pictures of the brain highlighting the areas of inflammation, before and after the administration of a compound called Lipopolysaccharide or LPS, that is known to cause a mild degree of inflammation. The investigators will couple this study with two venous blood draws to measure the levels of circulating molecules of inflammation.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Feb 2022 Aug 2025

OBSERVATIONAL

Intervention Type : DRUG
Intervention Description : All participants will receive one dose of Lipopolysaccharide (1ng/Kg) after the first PET/MR scan with \[11C\]PBR28 and four hours before the second PET/MR scan with \[11C\]PBR28.

Intervention Arm Group : Healthy controls;Parkinson's disease patients;

Intervention Type : RADIATION
Intervention Description : A PET/MR scan using the tracer \[11C\]PBR28 will be performed to all participants before and four hours after the administration of LPS

Intervention Arm Group : Healthy controls;Parkinson's disease patients;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University of Exeter
    Exeter

Heather Wilson, MSc Ph.D 07889950086
h.wilson4@exeter.ac.uk


Edoardo R. de Natale, MD MSc Ph.D 07503741242
e.de-natale@exeter.ac.uk



The study is sponsored by University of Exeter




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Read full details for Trial ID: NCT05205291
Last updated 30 November 2023

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