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Be Part of Research - Trial Details - A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors

A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors

Not Recruiting

Open to: ALL

Age: 0.5 - 21.0

Medical Conditions

Medullary Thyroid Cancer
Infantile Myofibromatosis
Infantile Fibrosarcoma
Papillary Thyroid Cancer
Soft Tissue Sarcoma


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


This is an open-label, multi-center Phase 1/2 study of oral LOXO-292 in pediatric participants with an activating rearranged during transfection (RET) alteration and an advanced solid or primary CNS tumor.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Jun 2019 Nov 2024

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Oral LOXO-292

Intervention Arm Group : Cohort 1: Medullary Thyroid Cancer (MTC) Group;Cohort 2: Papillary Thyroid Cancer (PTC) Group;Cohort 3: Other Cancer Group;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University College Hospital - London
    London
    Greater London
    NW1 2BU


The study is sponsored by Eli Lilly and Company and is in collaboration with Loxo Oncology, Inc..




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Read full details for Trial ID: NCT03899792
Last updated 02 January 2026

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