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Be Part of Research - Trial Details - A Study of Acalabrutinib Plus Venetoclax and Rituximab in Participants With Treatment NaĂŻve Mantle Cell Lymphoma

A Study of Acalabrutinib Plus Venetoclax and Rituximab in Participants With Treatment NaĂŻve Mantle Cell Lymphoma

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Lymphoma
Lymphoma, Mantle-Cell


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


TrAVeRse is a multicentre, open-label, Phase II study of AVR in treatment naĂŻve MCL participants. The primary objective will be to assess the rate of MRD-negative CR at end of induction after completing 13 cycles of AVR. Participants achieving an MRD-negative CR at the end of AVR induction will be randomised to continued acalabrutinib or observation. Participants who progress during observation may receive retreatment with acalabrutinib

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2023 Jul 2028

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : Investigational Product

Intervention Arm Group : Acalabrutinib + Venetoclax + Rituximab;

Intervention Type : DRUG
Intervention Description : Investigator Product

Intervention Arm Group : Acalabrutinib + Venetoclax + Rituximab;

Intervention Type : DRUG
Intervention Description : Investigator Product

Intervention Arm Group : Acalabrutinib + Venetoclax + Rituximab;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Research Site
    London
    SW3 6JJ
  • Research Site
    Nottingham
    NG5 1PB
  • Research Site
    Birmingham
    B9 5SS
  • Research Site
    Norwich
    NR4 7UY
  • Research Site
    Gloucester
    GL1 3NN
  • Research Site
    Plymouth
    PL68BQ


The study is sponsored by AstraZeneca




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Read full details for Trial ID: NCT05951959
Last updated 03 March 2025

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