Ask to take part

Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Dr Rachel Royston
+44 (0)203 108 7815
r.royston@ucl.ac.uk


Prof Angela Hassiotis
+44 (0)2079743788
a.hassiotis@ucl.ac.uk


Ms Rebecca Griffiths
+44 (0)20 7679 9319
rebecca.griffiths@ucl.ac.uk


More information about this study, what is involved and how to take part can be found on the study website.

Study Location:

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Be Part of Research - Trial Details - Personalised treatment packages for adults with a learning disability

Personalised treatment packages for adults with a learning disability

Medical Conditions

Intellectual disability


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The PETAL programme is designed to help adults with a learning disability who display aggression and those who support them work together to better understand and meet the person’s individual needs. Although there are some issues that are commonly experienced, everyone is different, so a personalised approach is needed. 10-25% of adults with mild to severe learning disabilities display aggression. This behaviour affects their quality of life, leading to exclusion from social networks and community facilities including access to healthcare, placement breakdown, inability to stay in the family home, seclusion, overmedication etc.

A better understanding of the causes of an individual’s aggressive behaviour and coproducing a personalised treatment package could make a significant difference to their quality of life. We work with adults with a learning disability and their families and paid carers to develop the PETAL therapy to address aggression and test if it works better than the current approaches available.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

26 Jan 2024 30 Sep 2025

The PETAL therapy has four phases which are presented below:
1. Review the evidence about which psychosocial treatments for aggression work for adults with learning disabilities and for other client groups. We reviewed the manuals and how they are delivered.
2. Talk to adults with a learning disability who have good outcomes, and those with poorer outcomes, their family or paid carers and professionals. With those who reported things went well, we asked why they thought that was so. Where it did not go so well and explored what might have been more helpful.
3. Use routinely collected NHS data to assess how adults with a learning disability who display aggression respond to treatments. This enabled us to better understand what influences patient outcomes and to inform the design of PETAL therapy.
4. Use the findings from 1, 2 and 3, and worked with adults with learning disabilities, carers and professionals, to develop a personalised treatment package called PETAL therapy. We developed a manual. We will train NHS staff in how to deliver the personalised treatment package and will test whether it is practical and acceptable, making changes if needed.
5. Find out, in a large trial, whether the personalised treatment package makes a positive difference to the health and quality of life of adults with a learning disability and how cost-effective it is.


Adults with learning disabilities and their carers (family or paid)

You can take part if:


Current inclusion criteria as of 09/06/2023:

1. Aged 18 years or over
2. Living in the community (e.g., residential care home, supported living, family home)
3. Registered with and/or eligible to receive support from community learning disabilities services
4. Incidents of physical aggression to people or property for at least 3 months. It is likely that people will have several additional comorbid behaviours such as verbal aggression, mental health problems, self-injury, stereotypies etc.
5. Consent to participate provided in keeping with UK capacity legislation or assent from family/nominated consultees for those lacking capacity
6. Family carer/other member able to unders


You may not be able to take part if:


Current exclusion criteria as of 09/06/2023:

1. Currently being an inpatient 2. Alcohol or drug dependent3. Current enrolment in another clinical trial

_____

Previous exclusion criteria:

1. Not having an intellectual disability diagnosis2. Alcohol or drug dependent3. Current enrolment in another clinical trial


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Devon Partnership NHS Trust
    Wonford House Hospital Dryden Road
    Exeter
    EX2 5AF
  • Pennine Care NHS Foundation Trust
    225 Old Street
    Ashton-under-lyne
    OL6 7SR
  • Lincolnshire Partnership NHS Foundation Trust
    St George's Long Leys Road
    Lincoln
    LN1 1FS
  • North East London NHS Foundation Trust
    West Wing C E M E Centre Marsh Way
    Rainham
    RM13 8GQ
  • Southern Health and Social Care Trust
    Southern Area College of Nursing Craigavon Area Hospital 68 Lurgan Road, Portadown
    Craigavon
    BT63 5QQ
  • Western Health and Social Care Trust
    Mdec Building Altnagelvin Area Hospital Site Glenshane Road
    Londonderry
    BT47 6SB
  • South Eastern Health and Social Care Trust
    Trust Headquarters Ulster Hospital Upper Newtownards Road Dundonald
    Belfast
    BT16 1RH
  • Norfolk Community Health and Care NHS Trust
    Norwich Community Hospital Bowthorpe Road
    Norwich
    NR2 3TU
  • Tees, Esk and Wear Valleys NHS Foundation Trust
    Trust Headquarters West Park Hospital Edward Pease Way
    Darlington
    DL2 2TS
  • Northamptonshire Healthcare NHS Foundation Trust
    St Marys Hospital 77 London Road
    Kettering
    NN15 7PW
  • Birmingham Community Healthcare NHS Foundation Trust
    3 Priestley Wharf Holt Street Birmingham Science Park, Aston
    Birmingham
    B7 4BN
  • Hertfordshire Partnership University NHS Foundation Trust
    The Colonnades Beaconsfield Close
    Hatfield
    AL10 8YE
  • East London NHS Foundation Trust
    Robert Dolan House 9 Alie Street
    London
    E1 8DE
  • Cambridgeshire and Peterborough NHS Foundation Trust
    Elizabeth House, Fulbourn Hospital Fulbourn
    Cambridge
    CB21 5EF
  • Berkshire Healthcare NHS Trust Headquarters
    Skimped Hill Lane
    Bracknell
    RG12 1LH
  • Hounslow and Richmond Community Healthcare NHS Trust
    Thames House 180-194 High Street
    Teddington
    TW11 8HU
  • Oxford Health NHS Foundation Trust
    Littlemore Mental Health Centre Sandford Road Littlemore
    Oxford
    OX4 4XN
  • North London NHS Foundation Trust
    4th Floor, East Wing St. Pancras Hospital 4 St. Pancras Way
    London
    NW1 0PE
  • Leicestershire Partnership NHS Trust
    Room 100/110 Pen Lloyd Building County Hall Leicester Road
    Leicester
    LE3 8RA
  • Bradford District Care Trust
    Lynfield Mount Hospital Heights Lane
    Bradford
    BD9 6DP
  • Yourhealthcare Community Interest Company
    Hollyfield House 22 Hollyfield Road
    Surbiton
    KT5 9AL
  • Norfolk and Suffolk NHS Foundation Trust
    County Hall Martineau Lane
    Norwich
    NR1 2DH
  • NHS South East London Icb - 72q
    160 Tooley Street
    London
    SE1 2TZ

There are a number of potential benefits to this study. At the moment, there is not a consistent approach to the management of aggression in adults with intellectual disabilities across the UK. If the PETAL therapy is effective, then it could be rolled out in all NHS services for adults with intellectual disabilities. Without evidence, we cannot convince health and social care services to change their usual practices. In addition, professionals, family, and paid carers would have gained special skills to better support adults with intellectual disabilities with aggressive challenging behaviour. There are no identified disadvantages to taking part in this research. Nonetheless, there is a time commitment to attend the PETAL therapy sessions over a period of 14 weeks. In addition, each research visit and interview might last for about 1 hour. If you find the PETAL therapy sessions, the research visits, or the interview too long, you may request a break.

Prof Angela Hassiotis
+44 (0)2079743788
a.hassiotis@ucl.ac.uk


Dr Rachel Royston
+44 (0)203 108 7815
r.royston@ucl.ac.uk


Ms Rebecca Griffiths
+44 (0)20 7679 9319
rebecca.griffiths@ucl.ac.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by North London NHS Foundation Trust and funded by National Institute for Health and Care Research (NIHR) Programme Grant for Applied Research (PGfAR).




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Read full details for Trial ID: ISRCTN71781827

Or CPMS 53581

Last updated 09 April 2025

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