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Be Part of Research - Trial Details - A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy

A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy

Not Recruiting

Open to: ALL

Age: 18.0 - N/A

Medical Conditions

Urinary Bladder Neoplasms
Non-Muscle Invasive Bladder Neoplasms


This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


The purpose of this study is to evaluate the overall complete response (CR) rate in participants treated with TAR-200 in combination with cetrelimab (Cohort 1), or TAR-200 alone (Cohort 2), or cetrelimab alone (Cohort 3) with Carcinoma in Situ (CIS), with or without concomitant high-grade Ta or T1 papillary disease; and disease-free survival (DFS) in participants treated with TAR-200 alone with papillary disease only (Cohort 4).

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

Dec 2020 Nov 2026

INTERVENTIONAL

Intervention Type : DRUG
Intervention Description : TAR-200 will be administered transuretherally.

Intervention Arm Group : Cohort 1: TAR-200 and Cetrelimab;Cohort 2: TAR-200;Cohort 4: TAR-200 (Participants with Papillary Disease only);

Intervention Type : BIOLOGICAL
Intervention Description : Cetrelimab will be administered.

Intervention Arm Group : Cohort 1: TAR-200 and Cetrelimab;Cohort 3: Cetrelimab;



You can take part if:



You may not be able to take part if:


This is in the inclusion criteria above


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • NHS Greater Glasgow and Clyde
    Glasgow
    G12 0YN
  • Leeds Teaching Hospitals NHS Trust
    Leeds
    LS9 7TF


The study is sponsored by Janssen Research & Development, LLC




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Read full details for Trial ID: NCT04640623
Last updated 02 April 2025

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