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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Mr Matthew Osmond
-
Matthew.osmond@gstt.nhs.uk


Study Location:

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Be Part of Research - Trial Details - The effect of MultiPoint™ pacing on reverse remodelling and the incidence of ventricular arrhythmias – The MPP VARR Study
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The effect of MultiPoint™ pacing on reverse remodelling and the incidence of ventricular arrhythmias – The MPP VARR Study

Stopped

Open to: All Genders

Age: Adult

Basildon London

Medical Conditions

Abnormal heart rhythms

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Heart failure patients may benefit from Cardiac Resynchronisation Therapy (CRT), which involves having a special pacemaker implanted to help the heart pump in a more coordinated and efficient way. These pacemakers involve attaching a lead to the heart muscle in within the main heart chambers which delivers current to help the heart beat effectively (pacing leads). Current pacing leads stimulate the main chamber of the heart from one location. Only two thirds of people respond to CRT and this may be due to the need to stimulate the heart from more than one position. Previous attempts at using two pacing leads in the main chamber of the heart have proved technically difficult. Due to new technologies it is now possible to stimulate the heart from more than one site using one lead - MultiPoint™ Pacing (MPP). This lead can also function as a conventional pacing lead if the MPP mode is switched off. The aim of this study is to use this specialised lead in the main chamber of the heart and study the outcomes of patients with the MPP on and MPP off.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

26 Oct 2016 26 Oct 2020

Participants are randomly allocated to one of two groups. Those in the first group have their pacemaker set using the conventional method of pacing the left side of the heart from one location. Those in the second group have their pacemaker set to stimulate the left side from two locations. Participants in both groups are followed up for two years in order to find out how many episodes of irregular heart rate problems participants experience after they have had their pacemakers placed.


Adults who are scheduled to have a CRT device implanted.

You can take part if:



You may not be able to take part if:


1. Recent myocardial infarction within 40 days prior to enrolment 2. Cardiac surgery or coronary revascularisation procedure within 3 months prior to enrolment or be scheduled for such procedures in the following 7 months 3. Intravenous inotropic support within the last 30 days 4. Under 18 years of age 5. Be pregnant or plan to become pregnant over the next 7 months


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • Basildon Hospital
    Nethermayne
    Basildon
    SS16 5NL
  • St Thomas Hospital
    Westminster Bridge Road
    London
    SE1 7EH

Participants may not benefit from taking part in this study. It is not known as to whether stimulating the main chamber of the heart from two locations will improve the effectiveness of pacemaker treatment. Although early work suggests that this will be beneficial, these benefits have not been proven in large studies yet, and this is one of the reasons that this research is being carried out. The information from this study may therefore help with the treatment of other patients in the future. There are no notable risks involved with participating.

Mr Matthew Osmond
-
Matthew.osmond@gstt.nhs.uk



The study is sponsored by Guy's and St Thomas' NHS Foundation Trust and funded by St Jude Medical UK Ltd.



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Read full details for Trial ID: ISRCTN36496918
Last updated 23 May 2020

This page is to help you find out about a research study and if you may be able to take part

You can print or share the study information with your GP/healthcare provider or contact the research team directly.   

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