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Contact the study team using the details below to take part. If there are no contact details below please ask your doctor in the first instance.

Contact Information:

Prof Matthew Ridd
+44 (0)117 4552352
m.ridd@bristol.ac.uk


Ms Dominika Corejova
+44 (0)117 455 3039
d.corejova@bristol.ac.uk


More information about this study, what is involved and how to take part can be found on the study website.

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Be Part of Research - Trial Details - Trial of food allergy IgE tests for eczema relief
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Trial of food allergy IgE tests for eczema relief

Recruiting

Open to: All Genders

Age: Child

Southampton Manchester Bristol Bristol Southampton Oxford Manchester

Medical Conditions

Management of eczema in children aged between 3 months and 2 years

This information is provided directly by researchers, and we recognise that it isn't always easy to understand. We are working with researchers to improve the accessibility of this information. In some summaries, you may come across links to external websites. These websites will have more information to help you better understand the study.


Eczema is common in children and causes dry, itchy and inflamed skin. Symptoms tend to come and go, and there are many reasons why a worsening or “flare” of eczema can happen. Many parents wonder whether a food allergy might be a cause, however, there is currently no good research evidence to support this.
The TIGER study is designed to help doctors and parents understand whether making changes to the diet of children with eczema, based on the results of food allergy tests, improves eczema control or not. The foods we are looking at are cow’s milk, hen’s egg, wheat and soya. Previous research into any link between food allergy and eczema symptoms is limited. This study is needed to help parents and doctors in the future know what is the best thing to do.

Start dates may differ between countries and research sites. The research team are responsible for keeping the information up-to-date.  

The recruitment start and end dates are as follows:

01 Mar 2023 31 Aug 2025

To find out if food allergy testing can improve eczema control, two groups of children (with equal numbers in each group) will be compared. We aim to run the study in up to 123 GP practices in England. Children will attend a study appointment at their GP surgery (or a nearby GP surgery) at the start of the study. During this appointment, children will have a skin assessment, and their growth will be measured. They will also be allocated to one of the two study groups by a process called randomisation. This means that nobody involved (the participants, their GP or the study team) decides or can predict which group each child gets put into. One group of children will receive standard care from their GP plus our ‘Good eczema care’ leaflet. The other group will also receive the leaflet plus they will be given dietary advice to follow for four study foods (cow’s milk, hen’s egg, wheat and soya) based on results from their food allergy tests (skin prick tests). A few children from the dietary advice group may be asked to attend the hospital for a day to make sure that all study foods are safe to eat at home, this is called an Oral Food Challenge. All children in the study will be followed up for 9 months and parents will be asked to complete study questionnaires about their child’s eczema symptoms, treatment use and diet every month during this time. All children will have a follow-up appointment 6 months after their first study appointment, at a time and place of their convenience to re-assess their skin and growth.


Children aged between 3 months and 2 years, diagnosed with eczema who have not had a previous food allergy test or had an immediate reaction to the study foods (cow’s milk, hen’s egg, wheat and soya)

You can take part if:



You may not be able to take part if:


1. Confirmed or probable* immediate (IgE-type) food allergy to the study foods2. Previous skin prick test (SPT) or IgE blood test for the study foods3. Another child in the household already taking part in the trial

* Parents who report symptoms, which in the opinion of the allergy panel/their GP, are suspicious of an immediate-type reaction.


Below are the locations for where you can take part in the trial. Please note that not all sites may be open.

  • University Hospital Southampton NHS Foundation Trust
    Southampton General Hospital Tremona Road
    Southampton
    SO16 6YD
  • Manchester University NHS Foundation Trust
    Cobbett House Oxford Road
    Manchester
    M13 9WL
  • University Hospitals Bristol and Weston NHS Foundation Trust
    Trust Headquarters Marlborough Street
    Bristol
    BS1 3NU
  • NIHR CRN: West of England
    Whitefriars Lewins Mead
    Bristol
    BS1 2NT
  • NIHR CRN: Wessex
    Unit 7 Berrywood Business Village Tollbar Way Hedge End
    Southampton
    SO30 2UN
  • NIHR CRN: Thames Valley and South Midlands
    John Radcliffe Hospital Headley Way Headington
    Oxford
    OX3 9DU
  • NIHR CRN: Greater Manchester
    2nd Floor Citylabs Nelson Street
    Manchester
    M13 9NQ

This information has not yet been provided by the study team. You'll have an opportunity to discuss any risks and benefits that may be associated with this study prior to consenting to taking part.

Prof Matthew Ridd
+44 (0)117 4552352
m.ridd@bristol.ac.uk


Ms Dominika Corejova
+44 (0)117 455 3039
d.corejova@bristol.ac.uk



More information about this study, what is involved and how to take part can be found on the study website.


The study is sponsored by University of Bristol and funded by National Institute for Health and Care Research.



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Read full details for Trial ID: ISRCTN52892540

Or CPMS 54714

Last updated 13 December 2024

This page is to help you find out about a research study and if you may be able to take part

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